SIX2

SIX2
Identifiers
Aliases	SIX2
External IDs	MGI: 102778 HomoloGene: 56518 GeneCards: 10736
Gene ontology Molecular function • DNA binding • sequence-specific DNA binding • transcription factor activity, sequence-specific DNA binding • protein complex binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • transcription factor binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding Cellular component • cytoplasm • nuclear membrane • plasma membrane • nucleoplasm • nucleus Biological process • embryonic skeletal system morphogenesis • regulation of chondrocyte differentiation • regulation of transcription, DNA-templated • positive regulation of chondrocyte proliferation • chondrocyte differentiation • protein import into nucleus • kidney development • negative regulation of cell differentiation • anatomical structure morphogenesis • mesenchymal stem cell maintenance involved in nephron morphogenesis • mesenchymal to epithelial transition involved in metanephros morphogenesis • mesenchymal cell differentiation involved in kidney development • mesenchymal stem cell proliferation • transcription from RNA polymerase II promoter • regulation of branching involved in ureteric bud morphogenesis • multicellular organism development • nephron morphogenesis • nephron development • middle ear morphogenesis • embryonic digestive tract morphogenesis • embryonic cranial skeleton morphogenesis • regulation of ossification • cell proliferation • mesodermal cell fate specification • anterior/posterior axis specification • metanephros development • cell migration • positive regulation of transcription from RNA polymerase II promoter • condensed mesenchymal cell proliferation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10736	20472
Ensembl	ENSG00000170577	ENSMUSG00000024134
UniProt	Q9NPC8 Q8TBA2	Q62232
RefSeq (mRNA)	NM_016932	NM_011380
RefSeq (protein)	NP_058628.3 NP_058628.3	NP_035510.1
Location (UCSC)	Chr 2: 45.01 – 45.01 Mb	Chr 17: 85.68 – 85.69 Mb
PubMed search
Wikidata
View/Edit Human	View/Edit Mouse

Homeobox protein SIX2 is a protein that in humans is encoded by the SIX2 gene.

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
• López-Ríos J, Tessmar K, Loosli F, et al. (2003). "Six3 and Six6 activity is modulated by members of the groucho family.". Development. 130 (1): 185–95. doi:10.1242/dev.00185. PMID 12441302. 
• Ikeda K, Watanabe Y, Ohto H, Kawakami K (2002). "Molecular interaction and synergistic activation of a promoter by Six, Eya, and Dach proteins mediated through CREB binding protein.". Mol. Cell. Biol. 22 (19): 6759–66. doi:10.1128/MCB.22.19.6759-6766.2002. PMC 134036. PMID 12215533. 
• Buller C, Xu X, Marquis V, et al. (2002). "Molecular effects of Eya1 domain mutations causing organ defects in BOR syndrome.". Hum. Mol. Genet. 10 (24): 2775–81. doi:10.1093/hmg/10.24.2775. PMID 11734542. 
• Boucher CA, Winchester CL, Hamilton GM, et al. (2000). "Structure, mapping and expression of the human gene encoding the homeodomain protein, SIX2.". Gene. 247 (1–2): 145–51. doi:10.1016/S0378-1119(00)00105-0. PMID 10773454. 
• Celli J, van Beusekom E, Hennekam RC, et al. (2000). "Familial syndromic esophageal atresia maps to 2p23-p24". Am. J. Hum. Genet. 66 (2): 436–44. doi:10.1086/302779. PMC 1288096. PMID 10677303. 
• Kawakami K, Ohto H, Takizawa T, Saito T (1996). "Identification and expression of six family genes in mouse retina". FEBS Lett. 393 (2–3): 259–63. doi:10.1016/0014-5793(96)00899-X. PMID 8814301.