Transcription factor II E
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| general transcription factor IIE, polypeptide 1, alpha 56kDa | |
|---|---|
| Identifiers | |
| Symbol | GTF2E1 |
| Alt. symbols | TF2E1 |
| Entrez | 2960 |
| HUGO | 4650 |
| OMIM | 189962 |
| RefSeq | NM_005513 |
| UniProt | P29083 |
| Other data | |
| Locus | Chr. 3 q21-q24 |
| general transcription factor IIE, polypeptide 2, beta 34kDa | |
|---|---|
| Identifiers | |
| Symbol | GTF2E2 |
| Alt. symbols | TF2E2 |
| Entrez | 2961 |
| HUGO | 4651 |
| OMIM | 189964 |
| RefSeq | NM_002095 |
| UniProt | P29084 |
| Other data | |
| Locus | Chr. 8 p12 |
Transcription factor II E (TFIIE) is one of several general transcription factors that make up the RNA polymerase II preinitiation complex.[1]
Transcription Factor II E is encoded by the GTF2E1 and GTF2E2 genes.[2][3][4][5] TFIIE is thought to be involved in DNA melting at the promoter: it contains a zinc ribbon motif that can bind single stranded DNA.[6]
See also[edit]
References[edit]
- ^ Lewin, Benjamin (2004). Genes VIII. Upper Saddle River, NJ: Pearson Prentice Hall. pp. 636–637. ISBN 0-13-144946-X.
- ^ Ohkuma Y, Hashimoto S, Roeder RG, Horikoshi M (1992). "Identification of two large subdomains in TFIIE-alpha on the basis of homology between Xenopus and human sequences". Nucleic Acids Res. 20 (21): 5838. doi:10.1093/nar/20.21.5838. PMC 334425
. PMID 1454543. - ^ Heng HH, Xiao H, Shi XM, Greenblatt J, Tsui LC (1994). "Genes encoding general initiation factors for RNA polymerase II transcription are dispersed in the human genome". Hum. Mol. Genet. 3 (1): 61–4. doi:10.1093/hmg/3.1.61. PMID 8162052.
- ^ Sumimoto H, Ohkuma Y, Sinn E, Kato H, Shimasaki S, Horikoshi M, Roeder RG (1991). "Conserved sequence motifs in the small subunit of human general transcription factor TFIIE". Nature. 354 (6352): 401–4. doi:10.1038/354401a0. PMID 1956404.
- ^ Ohkuma Y, Sumimoto H, Hoffmann A, Shimasaki S, Horikoshi M, Roeder RG (December 1991). "Structural motifs and potential sigma homologies in the large subunit of human general transcription factor TFIIE". Nature. 354 (6352): 398–401. doi:10.1038/354398a0. PMID 1956403.
- ^ Lee TI, Young RA (2000). "Transcription of eukaryotic protein-coding genes". Annu. Rev. Genet. 34: 77–137. doi:10.1146/annurev.genet.34.1.77. PMID 11092823.
External links[edit]
- Transcription Factor TFIIE at the US National Library of Medicine Medical Subject Headings (MeSH)
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