From Wikipedia, the free encyclopedia
Activating Protein 2 (AP-2) is a family of closely related transcription factors[1][2] which plays a critical role in regulating gene expression during early development.[3]
References[edit]
- ^ Williams T, Tjian R (1991). "Characterization of a dimerization motif in AP-2 and its function in heterologous DNA-binding proteins". Science. 251 (4997): 1067–71. doi:10.1126/science.1998122. PMID 1998122.
- ^ Williams T, Tjian R (1991). "Analysis of the DNA-binding and activation properties of the human transcription factor AP-2". Genes Dev. 5 (4): 670–82. doi:10.1101/gad.5.4.670. PMID 2010091.
- ^ Hilger-Eversheim K, Moser M, Schorle H, Buettner R (2000). "Regulatory roles of AP-2 transcription factors in vertebrate development, apoptosis and cell-cycle control". Gene. 260 (1-2): 1–12. doi:10.1016/S0378-1119(00)00454-6. PMID 11137286.
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(2) Zinc finger DNA-binding domains
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| (2.1) Nuclear receptor (Cys4) |
| subfamily 1 |
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| subfamily 2 |
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| subfamily 3 |
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| subfamily 4 |
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| subfamily 5 |
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| subfamily 6 |
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| subfamily 0 |
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| (2.2) Other Cys4 |
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| (2.3) Cys2His2 |
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| (2.4) Cys6 |
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| (2.5) Alternating composition |
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| (2.6) WRKY |
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(4) β-Scaffold factors with minor groove contacts
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(0) Other transcription factors
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