Starting in 1996, Alexa Internet has been donating their crawl data to the Internet Archive. Flowing in every day, these data are added to the Wayback Machine after an embargo period.
Starting in 1996, Alexa Internet has been donating their crawl data to the Internet Archive. Flowing in every day, these data are added to the Wayback Machine after an embargo period.
TIMESTAMPS
The Wayback Machine - https://web.archive.org/web/20160608173700/http://www.informatics.jax.org:80/function.shtml
Karen Christie presented a poster at the 2014 Keystone Symposia on Cilia, Development and Human Disease:
Karen R. Christie and Judith A. Blake. Comprehensive Gene Ontology annotation of ciliary genes in the laboratory mouse.
Li Ni presented a poster at the 2013 International Mammalian Genome Society meeting:
Li Ni, Mary E. Dolan, Judith A. Blake. Assessment of comparative functional annotation propagation in mouse.
Abstract: Annotations that have been curated from the literature by domain experts are considered the most valuable component of this effort, but manual curation is very labor intensive compared with semi-automated methods for assignment of functional annotation. Since genes that share close evolutionary relationships are likely to function in similar ways, many applications leverage phylogenetic relationships to propagate functional annotation from related genes. MGI's use of N:M homology sets has led to the refinement of rules for semi-automated annotation propagation. In this work we assess the quantity and quality of various methods of automated propagation of functional annotations.
MGI has long provided one-to-one orthologous mammalian relationships and used these to infer the function of mouse genes from experimentally determined knowledge about human and rat genes. Recently, MGI implemented a "many-to-many" homology paradigm to better reflect current understanding about the relationships between genes of these three organisms. Although one-to-one orthology assertions between mouse/human/rat genes still holds for 90% of protein-coding genes, MGI can now more clearly represent cases where phylogenetic analysis shows multiple mouse, human, or rat genes in the same orthology class.
MGI-Mouse Functional Annotation using the Gene Ontology (GO): About GO - Functional Annotation using the Gene Ontology (GO): About
The Mouse Genome Informatics group is a founding member of the Gene Ontology Consortium
(www.geneontology.org). MGI fully incorporates
the GO in the database and provides a GO browser.
Analysis Tools
