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Definition (NCI)
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Brain natriuretic peptide 32 (32 aa, ~3 kDa) is encoded by the human NPPB gene. This protein plays a role in the modulation of diuresis, vasorelaxation and secretion of renin and aldosterone.
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Definition (NCI)
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A recombinant version of the cardiac neurohormone, human B-type natriuretic peptide (hBNP) produced by the ventricular myocardium. Nesiritide binds to natriuretic peptide receptors on vascular smooth muscle and endothelial cells, through which it triggers guanylate cyclase dependent signal transduction resulting in increase of intracellular concentrations of cGMP. This leads to smooth muscle cell relaxation causing arterial and venous dilatation.
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Definition (MSH)
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A PEPTIDE that is secreted by the BRAIN and the HEART ATRIA, stored mainly in cardiac ventricular MYOCARDIUM. It can cause NATRIURESIS; DIURESIS; VASODILATION; and inhibits secretion of RENIN and ALDOSTERONE. It improves heart function. It contains 32 AMINO ACIDS.
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Definition (PDQ)
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A recombinant version of the cardiac neurohormone, human B-type natriuretic peptide (hBNP) produced by the ventricular myocardium. Nesiritide binds to natriuretic peptide receptors on vascular smooth muscle and endothelial cells, through which it triggers guanylate cyclase dependent signal transduction resulting in increase of intracellular concentrations of cGMP. This leads to smooth muscle cell relaxation causing arterial and venous dilatation. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=434520&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=434520&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C47636" NCI Thesaurus)
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| Concepts |
Pharmacologic Substance
(T121)
, Amino Acid, Peptide, or Protein
(T116)
, Hormone
(T125)
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| MSH |
D020097
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| SnomedCT |
385678006, 385677001, 385680000, 385679003, 407059007 |
| English |
Nesiritide (HBNP), 1,2-Dithia-5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50-hexadecaazacyclotripentacontane, Cyclic Peptide Derivative, L-Histidine, L-seryl-L-prolyl-L-lysyl-L-methionyl-L-valyl-L-glutaminylglycyl-L-serylglycyl-L-cysteinyl-L-phenylalanylglycyl-L-arginyl-L-lysyl-L-methionyl-L-alpha-aspartyl-L-arginyl-L-isoleucyl-L-seryl-L-seryl-L-seryl-L-serylglycyl-L-leucylglycyl-L-cysteinyl-L-lysyl-L-valyl-L-leucyl-L-arginyl-L-arginyl-, Cyclic (10-26)-disulfide, Human Brain Natriuretic Factor-32, Natriuretic factor-32, Natriuretic factor, brain, Brain Natriuretic Peptide, Natriuretic Peptide, Brain, Peptide, Brain Natriuretic, nesiritide (medication), nesiritide, Nesiritide, NESIRITIDE, Natriuretic Peptide, Brain [Chemical/Ingredient], b-type natriuretic peptide, brain natriuretic peptides, brain natriuretic peptide, b type natriuretic peptide, b type natriuretic peptides, brain natriuretic factor, type b natriuretic peptide, Brain Natriuretic Peptide 32, BNP(1-32), Human B-type natriuretic peptide (substance), BNP-32, B-Type Natriuretic Peptide, BNP 32, BNP Gene Product, Brain Natriuretic Peptide-32, Natriuretic Factor 32, Natriuretic Factor-32, Natriuretic Peptide Type B, Natriuretic Peptide Type-B, Natriuretic Peptide, B-Type, Natriuretic Peptide, Type-B, Natriuretic Peptide-32, Brain, Peptide-32, Brain Natriuretic, Type-B Natriuretic Peptide, Type B Natriuretic Peptide, Human B-type natriuretic peptide (product), Human B-type natriuretic peptide, Nesiritide (product), Nesiritide (substance), Brain natriuretic peptide (substance), Natriuretic Peptide B Type, B-type natriuretic peptide, Brain natriuretic peptide |
| Portuguese |
PeptÃdeo Encefálico Natriurético, PeptÃdeo Natriurético Encefálico, PeptÃdeo Natriurético Cerebral, PeptÃdeo Cerebral Natriurético, Nesiritida |
| Spanish |
Péptido Natriurético Encefálico, Péptido Encefálico Natriurético, péptido natriurético cerebral humano de tipo B, nesiritide (sustancia), nesiritide, nesiritida (sustancia), péptido natriurético humano tipo B (sustancia), Péptido Cerebral Natriurético, Péptido Natriurético Cerebral, nesiritida (producto), nesiritida, péptido natriurético humano tipo B (producto), péptido natriurético humano tipo B, péptido natriurético cerebral (sustancia), péptido natriurético cerebral, péptido natriurético tipo B, Nesiritida |
| Swedish |
Natriuretisk peptid, hjärna
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| Czech |
natriuretický peptid typu B, B-natriuretický peptid, natriuretický peptid B, BNP, mozkový natriuretický peptid, nesiritid |
| Finnish |
B-tyypin natriureettinen peptidi
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| French |
Facteur natriurétique de type B, BNP-32, Peptide cérébral natriurétique, Peptide natriurétique de type B, Nésiritide, BNP32, BNP (Brain Natriuretic Peptide), Peptide natriurétique cérébral, Produit du gène BNP |
| Russian |
NATRIIURETICHESKII PEPTID MOZGA, MOZGA GOLOVNOGO NATRIIURETICHESKII PEPTID, NATRIIURETICHESKII PEPTID MOZGOVOI, ��ТРИЙУРЕТИЧЕСКИЙ ПЕПТИД МОЗГОВОЙ, ��ТРИЙУРЕТИЧЕСКИЙ ПЕПТИД МОЗГ�, МОЗГ� ГОЛОВ�ОГО ��ТРИЙУРЕТИЧЕСКИЙ ПЕПТИД |
| Japanese |
脳性ナトリウム利尿ペプタイド, 脳性利尿ペプ�ド, ナトリウム利尿ペプ�ド-脳性, 脳ナトリウム利尿ペプ�ド, 脳内ナトリウム利尿ペプ�ド, ナトリウム利尿ペプ�ド-B型, クエン酸�シリ�ド, 脳性ナトリウム利尿ペプ�ド, �シリ�ド, �シリ�ドクエン酸塩, B型ナトリウム利尿ペプ�ド |
| Polish |
Peptyd natriuretyczny mózgowy
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| Croatian |
MOŽDANI NATRIJURETSKI PEPTID, NATRIURETSKI PEPTID, MOŽDANI, NATRIJURETSKI PEPTID, MOŽDANI |
| Norwegian |
Natriuretisk faktor-32, Type-B-natriuretisk peptid, Natriuretisk peptid type-B, Nesiritid, Natriuretisk peptid, hjerne, Hjernenatriuretisk peptid, B-type natriuretisk peptid, BNP-32 |
| German |
Gehirn, natriuretisches Peptid, Natriuretisches Peptid, Gehirn |
| Italian |
Peptide natriuretico del cervello
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