Adiponectin receptor 2

Adiponectin receptor 2
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	3WXW
Identifiers
Symbols	ADIPOR2 ; ACDCR2; PAQR2
External IDs	OMIM: 607946 HomoloGene: 56119 GeneCards: ADIPOR2 Gene
Gene ontology
Molecular function	• receptor activity; • hormone binding; • identical protein binding; • metal ion binding; • protein heterodimerization activity; • adiponectin binding; • adipokinetic hormone receptor activity;
Cellular component	• plasma membrane; • integral component of membrane; • intrinsic component of plasma membrane;
Biological process	• G-protein coupled receptor signaling pathway; • heart development; • female pregnancy; • response to nutrient; • hormone-mediated signaling pathway; • fatty acid oxidation; • negative regulation of cell growth; • adiponectin-activated signaling pathway; • glucose homeostasis; • positive regulation of glucose import; • vascular wound healing;
	Sources: Amigo / QuickGO
Orthologs
	v; t; e;

Adiponectin receptor 2 (AdipoR2) is a protein which in humans is encoded by the ADIPOR2 gene.^[1]

Structure[edit]

Similar to G protein-coupled receptors (GPCRs), AdipoR2 also possesses 7 transmembrane domains. However, AdipoR2 is orientated oppositely to GPCRs in the membrane (i.e., cytoplasmic N-terminus, extracellular C-terminus) and does not associate with G proteins.^[1]

The adiponectin receptors, AdipoR1 and AdipoR2, serve as receptors for globular and full-length adiponectin and mediate increased AMPK and PPAR-α ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin.^[1]

^ ^a ^b ^c Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, Sugiyama T, Miyagishi M, Hara K, Tsunoda M, Murakami K, Ohteki T, Uchida S, Takekawa S, Waki H, Tsuno NH, Shibata Y, Terauchi Y, Froguel P, Tobe K, Koyasu S, Taira K, Kitamura T, Shimizu T, Nagai R, Kadowaki T (June 2003). "Cloning of adiponectin receptors that mediate antidiabetic metabolic effects". Nature 423 (6941): 762–9. doi:10.1038/nature01705. PMID 12802337.
^ ^a ^b ^c Otvos L, Knappe D, Hoffmann R, Kovalszky I, Olah J, Hewitson TD, Stawikowska R, Stawikowski M, Cudic P, Lin F, Wade JD, Surmacz E, Lovas S (2014). "Development of second generation peptides modulating cellular adiponectin receptor responses". Front Chem 2: 93. doi:10.3389/fchem.2014.00093. PMC: 4201147. PMID 25368867.
^ Okada-Iwabu M, Yamauchi T, Iwabu M, Honma T, Hamagami K, Matsuda K, Yamaguchi M, Tanabe H, Kimura-Someya T, Shirouzu M, Ogata H, Tokuyama K, Ueki K, Nagano T, Tanaka A, Yokoyama S, Kadowaki T (2013). "A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity". Nature 503 (7477): 493–9. doi:10.1038/nature12656. PMID 24172895.
^ ^a ^b ^c ^d Sun Y, Zang Z, Zhong L, Wu M, Su Q, Gao X, Zan W, Lin D, Zhao Y, Zhang Z (2013). "Identification of adiponectin receptor agonist utilizing a fluorescence polarization based high throughput assay". PLoS ONE 8 (5): e63354. doi:10.1371/journal.pone.0063354. PMC: 3653934. PMID 23691032.

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