Tedatioxetine
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| Systematic (IUPAC) name | |
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4-{2-[(4-methylphenyl)sulfanyl]phenyl}piperidine
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| Identifiers | |
| CAS Number | 508233-95-2  |
| ATC code | none |
| PubChem | CID 9878913 |
| ChemSpider | 8054590 |
| KEGG | D10170  |
| Synonyms | Lu AA24530; Lu-AA-24530 |
| Chemical data | |
| Formula | C18H21NS |
| Molar mass | 283.43 g/mol |
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Tedatioxetine (Lu AA24530) is an antidepressant that was discovered by scientists at Lundbeck; in 2007 Lundbeck and Takeda entered into a partnership that included tedatioxetine but was focused on another, more advanced Lundbeck drug candidate, vortioxetine.[1]
Tedatioxetine is reported to act as a triple reuptake inhibitor (5-HT > NE > DA) and 5-HT2A, 5-HT2C, 5-HT3 and α1A-adrenergic receptor antagonist.[2][3][4][5]
As of 2009, it was in phase II clinical trials for major depressive disorder,[5] but there have been no updates since then, and as of August 2013 it was no longer displayed on Lundbeck's product pipeline.[6][7]
On May 10, 2016, all work on Tedatioxetine stopped.[8]
See also[edit]
References[edit]
- ^ Daniel Beaulieu for First Word Pharma. September 5th, 2007 Lundbeck, Takeda enter strategic alliance for mood disorder, anxiety drugs
- ^ "Patent US20100144788 - 4- [2- (4-methylphenylsulfanyd-phenyl] piperidine with combined serotonin and norepinephrine reuptake inhibition for the treatment of adhd, melancholia, treatment resistant depression or residual symptoms in depression". Retrieved 7 April 2014.
- ^ Stephen M. Stahl (19 May 2008). Depression and bipolar disorder: Stahl's essential psychopharmacology. Cambridge University Press. p. 206. ISBN 978-0-521-88663-5. Retrieved 22 November 2011.
- ^ Ian P. Stolerman (30 August 2010). Encyclopedia of Psychopharmacology. Springer. p. 105. ISBN 978-3-540-68698-9. Retrieved 22 November 2011.
- ^ a b "Lu AA24530 shows positive results in major depressive disorder phase II study - FierceBiotech".
- ^ "Pipeline of Lundbeck". Retrieved 25 August 2013.
- ^ UK Medicines Information Tedatioxetine entry in UKMI. Page accessed January 20, 2016
- ^ "Tedatioxetine - AdisInsight". adisinsight.springer.com. Retrieved 2016-06-09.
External links[edit]
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