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Title:
Isolation and Structure of a Brain Constituent That Binds to the Cannabinoid Receptor
Authors:
Devane, William A.; Hanus, Lumir; Breuer, Aviva; Pertwee, Roger G.; Stevenson, Lesley A.; Griffin, Graeme; Gibson, Dan; Mandelbaum, Asher; Etinger, Alexander; Mechoulam, Raphael
Publication:
Science, Volume 258, Issue 5090, pp. 1946-1949 (Sci Homepage)
Publication Date:
12/1992
Origin:
JSTOR
DOI:
10.1126/science.1470919
Bibliographic Code:
1992Sci...258.1946D

Abstract

Arachidonylethanolamide, an arachidonic acid derivative in porcine brain, was identified in a screen for endogenous ligands for the cannabinoid receptor. The structure of this compound, which has been named "anandamide," was determined by mass spectrometry and nuclear magnetic resonance spectroscopy and was confirmed by synthesis. Anandamide inhibited the specific binding of a radiolabeled cannabinoid probe to synaptosomal membranes in a manner typical of competitive ligands and produced a concentration-dependent inhibition of the electrically evoked twitch response of the mouse vas deferens, a characteristic effect of psychotropic cannabinoids. These properties suggest that anandamide may function as a natural ligand for the cannabinoid receptor.
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