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I. Epidemiology

  1. Incidence: 9-33% of lactating women
  2. Most common in first few weeks and nearly all cases within first 3 months

II. Pathophysiology

  1. Generally occurs in Lactation several weeks postpartum
  2. Bacteria enter through a cracked nipple

IV. Symptoms

  1. Fatigue
  2. Malaise
  3. Myalgias
  4. Headache

V. Signs

  1. Fever
  2. Unilateral Breast inflammation
    1. Warmth
    2. Tenderness
    3. Erythema
  3. Observe for signs of Breast abscess
    1. Requires needle aspiration

VI. Labs: Milk Culture

  1. Indications (not routine)
    1. Severe Mastitis
    2. Refractory despite optimal antibiotics for at least 48 hours
    3. Hospital acquired infection
  2. Technique
    1. Cleanse nipple
    2. Hand express small quantity of Breast Milk and discard
    3. Hand express a sample into a sterile container

VII. Differential Diagnosis

  1. Inflammatory Breast Cancer

VIII. Management: General Measures

  1. Continue with frequent Breastfeeding
    1. Risk of Breast abscess if Breast engorgement occurs
    2. Safe for infant to continue to feed despite infection (except if mother HIV positive)
    3. Ensure proper technique (see prevention below)
  2. Tylenol
  3. Ensure adequate hydration
  4. Apply warm packs and local massage
  5. Alternate feeding positions
  6. Antifungals (Monilial Infection)
    1. Topical Antifungals on Breast
    2. Oral Nystatin for infant

IX. Management: Antibiotics

  1. Course: 10 to 14 days
  2. Coverage: Staphylococcus aureus (or as directed by culture)
  3. Antibiotics: Nursing Mothers
    1. Amoxacillin-Clavulanate (Augmentin) 875 mg orally twice daily
    2. Cephalexin (Keflex) 500 mg orally four times daily
    3. Dicloxacillin 500 mg orally four times daily
    4. Clindamycin 300 mg orally four times daily (for MRSA)
    5. Ciprofloxacin 500 mg orally twice daily (for MRSA)
  4. Antibiotics: Non-Breast Feeding women
    1. Trimethoprim-sulfamethoxazole (Septra) 160mg/800 mg orally twice daily (for MRSA)

X. Complications

  1. Breast abscess
    1. Obtain bacterial culture
    2. Treat with needle aspiration or Incision and Drainage

XI. Follow-up

  1. If not better in 48 hours examine Breast for abscess
    1. Consider Incision and Drainage
  2. Early antibiotics prevent abscess formation

XII. Prevention

  1. Optimal Breast Feeding Technique with good latch-on by infant
  2. Address predisposing factors early
    1. Sore nipples suggest problems
      1. Correct latch-on problems
      2. Address dry nipples with lanolin
      3. Avoid plastic-backed Breast pads
      4. Evaluate infant for anatomic problems (e.g. short frenulum, Cleft Palate)
    2. Cracked nipples colonized with Staphylococcus aureus should be treated
      1. Oral antibiotics (e.g. Dicloxacillin) are preferred
      2. Livingstone (1999) J Hum Lact 15:241-6 [PubMed]
    3. Blocked milk ducts should be unblocked
      1. Blocked ducts will appear with a bleb overlying a tender, red area adjacent to nipple
      2. Remove bleb with moist cloth
    4. Yeast infection should be treated (both infant and mother)
      1. Infant: See Thrush for management options
      2. Mother
        1. Topical agents: Nystatin or Ketoconazole
        2. Oral agents: Fluconazole 400 mg on day #1, then 200 mg orally daily for 10 days
        3. Chetwynd (2002) J Hum Lact 18:168-71 [PubMed]

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Ontology: Mastitis (C0024894)

Definition (MSH) INFLAMMATION of the BREAST, or MAMMARY GLAND.
Concepts Pathologic Function (T046)
MSH D008413
SnomedCT 155952005, 155955007, 266644004, 198099006, 266641007, 45198002
French MASTITE, Inflammation du sein, INFLAMMATION DU SEIN, Mammite, Mastite
English BREAST INFLAMMATION, MASTITIS, Breast inflammation, Breast inflammation NOS, mastitis (diagnosis), mastitis, Mastitis [Disease/Finding], Mastitis, breasts inflammation, Breast inflammation NOS (disorder), Mammitis, Mastitis (disorder), breast; inflammation, inflammation; breast, Mastitis, NOS, Mastitis NOS
Portuguese MASTITE, Inflamação da mama, INFLAMACAO DA MAMA, Mamite, Mastite
Spanish MASTITIS, Inflamación mamaria, MAMA, INFLAMACION, inflamación mamaria, SAI, Breast inflammation NOS, inflamación mamaria, SAI (trastorno), Mamitis, mastitis (trastorno), mastitis, Mastitis
German MASTITIS, Brustentzuendung, BRUSTENTZUENDUNG, Mammitis, Mastitis
Japanese 乳腺炎, ニュウセ�エ�, 乳房炎症, ニュウボウエ�ショウ
Swedish Bröstkörtelinflammation
Dutch mastitis, borstontsteking, mammitis, mamma; ontsteking, ontsteking; mamma, Mastitis
Italian Infiammazione mammaria, Mammite, Mastite
Czech mastitida, Zánět prsu, Mastitida
Finnish Mastiitti
Russian MASTIT, М�СТИТ
Croatian MASTITIS
Polish Zapalenie sutka
Hungarian Emlő gyulladás, mastitis, Mammitis
Norwegian Brystkjertelbetennelse, Brystbetennelse, Mastitt
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