SOX1 (for Sex determining region Y-box 1) is a transcription factor in the Sox protein family. SOX1 expression is restricted to neuroectoderm in the tetrapod embryo.[1][2] SOX1 is involved in early central nervous system development, where it is functionally redundant with SOX3 and to a lesser degree SOX2, and maintenance of neural progenitor cell identity. SOX1 is expressed particularly in the ventral striatum, and Sox1-deficient mice have altered striatum development, leading e.g. to epilepsy.[1]
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References[edit]
- ^ a b Guth SI, Wegner M (October 2008). "Having it both ways: Sox protein function between conservation and innovation". Cell. Mol. Life Sci. 65 (19): 3000–18. doi:10.1007/s00018-008-8138-7. PMID 18516494.
- ^ Nitta KR, Takahashi S, Haramoto Y, Fukuda M, Onuma Y, Asashima M (December 2006). "Expression of Sox1 during Xenopus early embryogenesis". Biochem. Biophys. Res. Commun. 351 (1): 287–93. doi:10.1016/j.bbrc.2006.10.040. PMID 17056008.
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| (2.1) Nuclear receptor (Cys4) |
| subfamily 1 |
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| subfamily 2 |
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| subfamily 3 |
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| subfamily 4 |
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| subfamily 5 |
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| subfamily 6 |
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| subfamily 0 |
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| (2.2) Other Cys4 |
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| (2.3) Cys2His2 |
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| (2.4) Cys6 |
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| (2.5) Alternating composition |
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| (2.6) WRKY |
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(4) β-Scaffold factors with minor groove contacts
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(0) Other transcription factors
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Index of genetics
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| Description |
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