FOXJ1

Forkhead box protein J1 is a protein that in humans is encoded by the FOXJ1 gene. It has been shown that this gene is a transcription factor involved in ciliogenesis.

FOXJ1
Identifiers
Aliases	FOXJ1, FKHL13, HFH-4, HFH4, forkhead box J1
External IDs	MGI: 1347474 HomoloGene: 1117 GeneCards: 2302
Gene ontology Molecular function • transcription regulatory region sequence-specific DNA binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • sequence-specific DNA binding • RNA polymerase II transcription factor activity, sequence-specific DNA binding • DNA binding • transcription factor activity, sequence-specific DNA binding Cellular component • nucleus Biological process • determination of left/right symmetry • positive regulation of lung ciliated cell differentiation • cell projection organization • regulation of transcription, DNA-templated • metanephric part of ureteric bud development • pattern specification process • transcription, DNA-templated • glomerular parietal epithelial cell development • regulation of epithelial cell differentiation • transcription from RNA polymerase II promoter • negative regulation of T cell proliferation • left/right pattern formation • spermatogenesis • heart development • negative regulation of T cell differentiation in thymus • negative regulation of interleukin-6 biosynthetic process • cilium morphogenesis • establishment of apical/basal cell polarity • activation of GTPase activity • negative regulation of B cell activation • positive regulation of central B cell tolerance induction • negative regulation of transcription from RNA polymerase II promoter • epithelium development • negative regulation of humoral immune response mediated by circulating immunoglobulin • brain development • humoral immune response • negative regulation of germinal center formation • central tolerance induction • cilium assembly • negative regulation of NF-kappaB transcription factor activity • lung epithelium development • actin cytoskeleton organization • leukocyte migration • positive regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2302	15223
Ensembl	ENSG00000129654	ENSMUSG00000034227
UniProt	Q92949	Q61660
RefSeq (mRNA)	NM_001454	NM_008240
RefSeq (protein)	NP_001445.2	NP_032266.3
Location (UCSC)	Chr 17: 76.14 – 76.14 Mb	Chr 11: 116.33 – 116.34 Mb
PubMed search
Wikidata
View/Edit Human	View/Edit Mouse

Function

This gene encodes a member of the forkhead family of transcription factors. Similar genes in zebrafish and mouse have been shown to regulate the transcription of genes that control the production of motile cilia. The mouse ortholog also functions in the determination of left-right asymmetry.

Clinical significance

Polymorphisms in this gene are associated with systemic lupus erythematosus and allergic rhinitis.

Further reading

• Li CS, Zhang Q, Lim MK, et al. (2007). "Association of FOXJ1 polymorphisms with systemic lupus erythematosus and rheumatoid arthritis in Korean population.". Experimental & Molecular Medicine. 39 (6): 805–11. doi:10.1038/emm.2007.87. PMID 18160851. 
• Li CS, Chae SC, Lee JH, et al. (2006). "Identification of single nucleotide polymorphisms in FOXJ1 and their association with allergic rhinitis.". J. Hum. Genet. 51 (4): 292–7. doi:10.1007/s10038-006-0359-8. PMID 16518568. 
• Turner J, Roger J, Fitau J, et al. (2011). "Goblet cells are derived from a FOXJ1-expressing progenitor in a human airway epithelium.". Am. J. Respir. Cell Mol. Biol. 44 (3): 276–84. doi:10.1165/rcmb.2009-0304OC. PMID 20539013. 
• Murphy DB, Seemann S, Wiese S, et al. (1997). "The human hepatocyte nuclear factor 3/fork head gene FKHL13: genomic structure and pattern of expression.". Genomics. 40 (3): 462–9. doi:10.1006/geno.1996.4587. PMID 9073514. 
• Maiti AK, Bartoloni L, Mitchison HM, et al. (2000). "No deleterious mutations in the FOXJ1 (alias HFH-4) gene in patients with primary ciliary dyskinesia (PCD).". Cytogenet. Cell Genet. 90 (1-2): 119–22. doi:10.1159/000015645. PMID 11060460. 
• LeSimple P, van Seuningen I, Buisine MP, et al. (2007). "Trefoil factor family 3 peptide promotes human airway epithelial ciliated cell differentiation.". Am. J. Respir. Cell Mol. Biol. 36 (3): 296–303. doi:10.1165/rcmb.2006-0270OC. PMID 17008636. 
• Lim L, Zhou H, Costa RH (1997). "The winged helix transcription factor HFH-4 is expressed during choroid plexus epithelial development in the mouse embryo.". Proc. Natl. Acad. Sci. U.S.A. 94 (7): 3094–9. doi:10.1073/pnas.94.7.3094. PMC 20327. PMID 9096351. 
• Pelletier GJ, Brody SL, Liapis H, et al. (1998). "A human forkhead/winged-helix transcription factor expressed in developing pulmonary and renal epithelium.". Am. J. Physiol. 274 (3 Pt 1): L351–9. PMID 9530170. 
• Wu C, Ma MH, Brown KR, et al. (2007). "Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.". Proteomics. 7 (11): 1775–85. doi:10.1002/pmic.200601006. PMID 17474147. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.