P2ry2 MGI Mouse Gene Detail - MGI:105107 - purinergic receptor P2Y, G-protein coupled 2

P2ry2 Gene Detail

Symbol

P2ry2
Name

purinergic receptor P2Y, G-protein coupled 2
Synonyms

P2Y2

Feature Type

protein coding gene
IDs

MGI:105107
NCBI Gene: 18442

Sequence Map

Chr7:100996572-101011991 bp, - strand
From Ensembl annotation of GRCm38

Mouse Genome Browser
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Sequence

15420 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 54.47 cM, cytoband F1
Detailed Genetic Map ± 1 cM
Mapping Data

2 experiments

Human Ortholog

P2RY2, purinergic receptor P2Y, G-protein coupled, 2

Vertebrate Orthologs

9

Human Ortholog

P2RY2, purinergic receptor P2Y, G-protein coupled, 2
Orthology source: HGNC, HomoloGene
Synonyms

HP2U, P2RU1, P2U, P2U1, P2UR, P2Y2, P2Y2R
Links

HGNC:8541

NCBI Gene ID: 5029

neXtProt AC: NX_P41231
Chr Location

11q13.4; chr11:73216448-73242427 (+) GRCh38.p2

HomoloGene

Vertebrate Homology Class 1927
1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog
HCOP

human homology predictions: P2RY2
Protein SuperFamily

P2Y purinoceptors 1/2/3/4/6
Gene Tree

P2ry2

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Phenotype Summary

4 phenotypes from 1 allele in 2 genetic backgrounds
50 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryogenesis	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	tumorigenesis	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Radiation induced

1
Targeted

3
Genomic Mutations

1 involving P2ry2
Incidental Mutations

Mutagenetix , APF

Mice homozygous for a disruption in this gene display reduced nucleotide-stimulated calcium secretion from lung fibroblasts and nasal and tracheal epithelial cells and chloride secretion from trachea and gallbladder. Induction of neuronal differentiationby ATPgammaS is abolished.

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All GO Annotations

31
GO References

4

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1
Tissues

1
cDNA Data

17
Literature Summary

2

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase p2ry2

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P2ry2 interacts with 137 markers (Mir1a-1, Mir1a-2, Mir9-1, ...) View All

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All Sequences

28
RefSeq

6
UniProt

3
CCDS

CCDS21508.1
UniGene

3000

Ensembl

ENSMUSG00000032860 (Evidence)
NCBI Gene

18442 (Evidence)

Length	Strain/Species	Flank
genomic	ENSMUSG00000032860	Ensembl Gene Model \| MGI Sequence Detail	15420	C57BL/6J	± kb
transcript	ENSMUST00000178340	Ensembl \| MGI Sequence Detail	2139	Not Applicable
polypeptide	ENSMUSP00000137152	Ensembl \| MGI Sequence Detail	373	Not Applicable

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SNPs within 2kb

215 from dbSNP Build 137

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UniProt

3 Sequences
InterPro Domains

IPR017452 GPCR, rhodopsin-like, 7TM

IPR000276 G protein-coupled receptor, rhodopsin-like

IPR000356 P2Y2 purinoceptor

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All nucleic 17

cDNA 17

Microarray probesets 3

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MGD-MRK-32147

Summaries

All 82

Developmental Gene Expression 2

Gene Ontology 4

Phenotypes 50
Earliest

J:31197 Lustig KD, et al., Expression cloning of an ATP receptor from mouse neuroblastoma cells. Proc Natl Acad Sci U S A. 1993 Jun 1;90(11):5113-7
Latest

J:226966 Relvas LJ, et al., P2Y2R deficiency attenuates experimental autoimmune uveitis development. PLoS One. 2015;10(2):e0116518

Dec	JAN	Feb
	06
2015	2016	2017

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 12/29/2015 MGI 6.01