LPAR5
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| Lysophosphatidic acid receptor 5 | ||||||||
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| Identifiers | ||||||||
| Symbols | LPAR5 ; GPR92; GPR93; KPG_010; LPA5 | |||||||
| External IDs | OMIM: 606926 MGI: 2685918 HomoloGene: 10696 IUPHAR: 124 ChEMBL: 5700 GeneCards: LPAR5 Gene | |||||||
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| Orthologs | ||||||||
| Species | Human | Mouse | ||||||
| Entrez | 57121 | 381810 | ||||||
| Ensembl | ENSG00000184574 | ENSMUSG00000067714 | ||||||
| UniProt | Q9H1C0 | G3X9K0 | ||||||
| RefSeq (mRNA) | NM_001142961 | NM_001163268 | ||||||
| RefSeq (protein) | NP_001136433 | NP_001156740 | ||||||
| Location (UCSC) | Chr 12: 6.62 – 6.64 Mb |
Chr 6: 125.07 – 125.08 Mb |
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| PubMed search | [1] | [2] | ||||||
Lysophosphatidic acid receptor 5 also known as LPA5 is a protein that in humans is encoded by the LPAR5 gene.[1][2][3][4][5] LPA5 is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).[6]
See also[edit]
References[edit]
- ^ "Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23". Nat Genet 26 (3): 345–8. Dec 2000. doi:10.1038/81664. PMID 11062477.
- ^ Lee DK, Nguyen T, Lynch KR, Cheng R, Vanti WB, Arkhitko O, Lewis T, Evans JF, George SR, O'Dowd BF (Sep 2001). "Discovery and mapping of ten novel G protein-coupled receptor genes". Gene 275 (1): 83–91. doi:10.1016/S0378-1119(01)00651-5. PMID 11574155.
- ^ Lee CW, Rivera R, Gardell S, Dubin AE, Chun J (Aug 2006). "GPR92 as a new G12/13- and Gq-coupled lysophosphatidic acid receptor that increases cAMP, LPA5". J Biol Chem 281 (33): 23589–97. doi:10.1074/jbc.M603670200. PMID 16774927.
- ^ Kotarsky K, Boketoft A, Bristulf J, Nilsson NE, Norberg A, Hansson S, Owman C, Sillard R, Leeb-Lundberg LM, Olde B (Jul 2006). "Lysophosphatidic acid binds to and activates GPR92, a G protein-coupled receptor highly expressed in gastrointestinal lymphocytes". J Pharmacol Exp Ther 318 (2): 619–28. doi:10.1124/jpet.105.098848. PMID 16651401.
- ^ "Entrez Gene: GPR92 G protein-coupled receptor 92".
- ^ Choi JW, Herr DR, Noguchi K, Yung YC, Lee CW, Mutoh T, Lin ME, Teo ST, Park KE, Mosley AN, Chun J (January 2010). "LPA Receptors: Subtypes and Biological Actions". Annual Review of Pharmacology and Toxicology 50 (1): 157–186. doi:10.1146/annurev.pharmtox.010909.105753. PMID 20055701.
Further reading[edit]
- Takeda S, Kadowaki S, Haga T, Takaesu H, Mitaku S (2002). "Identification of G protein-coupled receptor genes from the human genome sequence". FEBS Lett. 520 (1–3): 97–101. doi:10.1016/S0014-5793(02)02775-8. PMID 12044878.
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