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Title:
G Protein Pathways
Authors:
Neves, Susana R.; Ram, Prahlad T.; Iyengar, Ravi
Affiliation:
AA(Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, NY 10029, USA.), AB(Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, NY 10029, USA.), AC(Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, NY 10029, USA.)
Publication:
Science, Volume 296, Issue 5573, pp. 1636-1639 (2002). (Sci Homepage)
Publication Date:
05/2002
Category:
CELL BIOL
Origin:
SCIENCE
Abstract Copyright:
(c) 2002: Science
DOI:
10.1126/science.1071550
Bibliographic Code:
2002Sci...296.1636N

Abstract

The heterotrimeric guanine nucleotide-binding proteins (G proteins) are signal transducers that communicate signals from many hormones, neurotransmitters, chemokines, and autocrine and paracrine factors. The extracellular signals are received by members of a large superfamily of receptors with seven membrane-spanning regions that activate the G proteins, which route the signals to several distinct intracellular signaling pathways. These pathways interact with one another to form a network that regulates metabolic enzymes, ion channels, transporters, and other components of the cellular machinery controlling a broad range of cellular processes, including transcription, motility, contractility, and secretion. These cellular processes in turn regulate systemic functions such as embryonic development, gonadal development, learning and memory, and organismal homeostasis.
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