Dopexamine
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| Systematic (IUPAC) name | |
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4-[2-({6-[(2-phenylethyl)amino]hexyl}amino)ethyl]benzene-1,2-diol
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| AHFS/Drugs.com | International Drug Names |
| Identifiers | |
| CAS Number | 86197-47-9  |
| ATC code | C01CA14 (WHO) |
| PubChem | CID 55483 |
| ChemSpider | 50102 |
| UNII | 398E7Z7JB5 |
| KEGG | D03891 |
| ChEMBL | CHEMBL77622 |
| Chemical data | |
| Formula | C22H32N2O2 |
| Molar mass | 429.43 g/mol |
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Dopexamine is a synthetic analogue of dopamine. Despite this, it is a β1 and β2 adrenoreceptor agonist.[1] Its agonism of peripheral[2] D1 dopamine receptors mediates relaxation of vascular smooth muscle in renal, mesenteric, cerebral and coronary arteries. Mild action at D2 receptors decreases norepinephrine (noradrenaline) release.
Use in sepsis has been proposed.[3]
It is used as an inotropic agent in cardiac failure.[4] Side effects include arrhythmia, tremor, angina and flushing.
References[edit]
- ^ Perrin G, Papazian L, Martin C. (1993). "Dopexamine: a new dopaminergic agonist". Ann Fr Anesth Reanim. 12 (3): 308–320. PMID 7902685.
- ^ Brown RA, Dixon J, Farmer JB; et al. (July 1985). "Dopexamine: a novel agonist at peripheral dopamine receptors and beta 2-adrenoceptors". Br. J. Pharmacol. 85 (3): 599–608. doi:10.1111/j.1476-5381.1985.tb10554.x. PMC 1916510. PMID 2862944.
- ^ Birnbaum J, Klotz E, Spies CD; et al. (2006). "Effects of dopexamine on the intestinal microvascular blood flow and leucocyte activation in a sepsis model in rats". Crit Care 10 (4): R117. doi:10.1186/cc5011. PMC 1750974. PMID 16893450.
- ^ Lisbon A (May 2003). "Dopexamine, dobutamine, and dopamine increase splanchnic blood flow: what is the evidence?". Chest 123 (5 Suppl): 460S–3S. doi:10.1378/chest.123.5_suppl.460S. PMID 12740229.
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