IV. Calculate Replacement and Replace Phase 1 Fluids
- Approach as per Pediatric Dehydration Management
- Deficit: 3500 - 700cc (Replaced Phase 1)
- Replacement
- First 8 hours
- Total: 1400 + (75 cc/hour for 8 hours)
- Hourly: 250 cc/hour for 8 hours (2 Liters over 8h)
- Next 16 hours
- Total: 1400 + (75 cc/hour for 16 hours)
- Hourly: 163 cc/hour for 16 hours (2.6L over 16h)
- First 8 hours
V. Calculate Sodium Deficit and Sodium Requirement
- Calculate Deficit
- Formula: 0.6 x (weight kg) x (135 - Serum Sodium)
- Example: (0.6 x 35 kilograms) x (135-120) = 315 meq
- Add Maintenance
- Formula: 3 meq/kg/day x (weight kg)
- Example: 35 kg x 3 meq = 105 meq Sodium/24 hours
- Subtract Replacement given Phase 1
VI. Choose Appropriate solution to replace Sodium deficit
- Available solutions
- 1/4 Normal Saline contains 38 meq/L Sodium
- 1/3 Normal Saline contains 51 meq/L Sodium
- 1/2 Normal Saline contains 77 meq/L Sodium
- Normal Saline contains 154 meq/L Sodium
- Example
- First 8 hours: Replace half Sodium deficit
- Sodium 157 meq in 2 Liters (78 meq/L)
- Fluid: 1/2 Normal Saline (77 meq/L)
- Next 16 hours: Replace half Sodium deficit
- Sodium 157 meq in 2.6 Liters (60 meq/L)
- Fluid: 1/2 Normal Saline (77 meq/L)
- First 8 hours: Replace half Sodium deficit
VII. Example Summary: 35 kg Child with hypotonic dehydration
- First 8 hours: D5 1/2NS with 20 KCl at 250 cc/hours
- Next 16 hours: D5 1/2NS with 20 KCl at 163 cc/hours
VIII. Monitoring
- Monitor Serum Sodium every 2-4 hours
- Raise Serum Sodium <= 2 meq/L/hours
IX. Special Circumstance: Hyponatremic Seizure
- Background
- Serum Sodium raised 5 meq/L with 6 ml/kg of 3% NaCl
- Protocol
- Give 3% NaCl (0.5 meq NaCl/ml) IV over 1 hour
- Give 3% NaCl at 6 ml/kg/hour until Seizure stops

