I. Indications: Preeclampsia risk factors
- Preeclampsia in prior pregnancy
- Chronic Hypertension
- Diabetes Mellitus
- Renal disease
- Advanced maternal age
II. Management: Aspirin 81 mg/day
- Indications (to start in first trimester)
- ACOG recommendations
- Prior Preeclampsia requiring delivery before 37 weeks OR
- More than one pregnancy with Preeclampsia
- USPTF recommendations (in addition to ACOG)
- Prior Severe Preeclampsia
- Diabetes Mellitus
- Chronic Hypertension
- Renal disease
- Autoimmune disease
- ACOG recommendations
- Efficacy: Benefits
- Prevents Pregnancy Induced Hypertension
- Prevents Intrauterine Growth Retardation
- Efficacy: Number Needed to Treat (NNT) to prevent one case of Preeclampsia
- NNT: 69 (overall)
- NNT: 18 (if highest risk factors present)
- References
III. Management: Calcium Supplementation
- Dose
- Calcium 1-2 g orally daily
- Indications
- Dietary Calcium <600 mg/day
- Efficacy: Benefits
- Lowers Preeclampsia risk
- Lowers Blood Pressure
- Systolic lowered 5.4 mmHg
- Diastolic lowered 3.4 mmhg
- Reference
IV. Management: Agents to avoid due to low efficacy
- Avoid routine Magnesium Supplementation
- Avoid routine Omega-3 Fatty Acid Supplementation
- Avoid antioxidant Vitamin Supplementation
V. References
- Fontaine (2000) in ALSO, B:1-36
- Sibai in Gabbe (2002) Obstetrics, p. 945-74
- (2000) Am J Obstet Gynecol 183(1):S1-22 [PubMed]
- Zamorski (2001) Clin Fam Pract 3:329-47 [PubMed]
