Lupitidine
From Wikipedia, the free encyclopedia
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| Systematic (IUPAC) name | |
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2-[2-[[5-(2-Aminopropan-2-yl)furan-2-yl]methylsulfanyl]ethylamino]-5-[(6-methylpyridin-3-yl)methyl]-1H-pyrimidin-6-one
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| Identifiers | |
| CAS Number | 83903-06-4 |
| ATC code | None |
| PubChem | CID 51670 |
| ChemSpider | 3577726 |
| UNII | WF028DWK9N  |
| KEGG | D04794 |
| Chemical data | |
| Formula | C21H27N5O2S |
| Molar mass | 413.54 g/mol |
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Lupitidine (INN) (code name SKF-93479), or lupitidine hydrochloride (USAN), is a long-acting H2 receptor antagonist[1] developed by Smith, Kline & French and described as an antiulcerogenic that was never marketed.[2] It was shown to inhibit nocturnal gastric acid secretion[3] and, in experiments on rodents, produced diffuse neuroendocrine cell hyperplasia and an increase in multifocal glandular hyperplasia due to hypergastrinemia resulting from the pharmacological suppression of gastric acid secretion.[4]
Synthesis[5][edit]
References[edit]
- ^ Franzén, L; Ghassemifar, R; Malcherek, P (July 1991). "Experimental Mast Cell Activation Improves Connective Tissue Repair in the Perforated Rat Mesentery". Agents and Actions 33 (3–4): 371–7. PMID 1683107.
- ^ J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 745–. ISBN 978-1-4757-2085-3.
- ^ Dammann, H.G.; Muller, P.; Simon, B. (January 1982). "Inhibition of Nocturnal Acid Secretion by H2-Receptor-Antagonist SKF 93479". The Lancet 319 (8265): 224. doi:10.1016/S0140-6736(82)90788-7.
- ^ Betton, GR; Dormer, CS; Wells, T; Pert, P; Price, CA; Buckley, P (1 February 1988). "Gastric ECL-Cell Hyperplasia and Carcinoids in Rodents Following Chronic Administration of H2-antagonists SK&F 93479 and Oxmetidine and Omeprazole". Toxicologic Pathology 16 (2): 288–298. doi:10.1177/019262338801600222. PMID 2903544.
- ^ Lam, B. L.; Pridgen, L. N.; 1982, U.S. Patent 4,352,933
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