Cevimeline
From Wikipedia, the free encyclopedia
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| Systematic (IUPAC) name | |
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2-Methyspiro(1,3-oxathiolane-5,3)quinuclidine
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| Clinical data | |
| Trade names | Evoxac |
| AHFS/Drugs.com | monograph |
| MedlinePlus | a608025 |
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| Routes of administration |
Oral |
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| Pharmacokinetic data | |
| Protein binding | < 20% |
| Identifiers | |
| CAS Number | 107233-08-9  |
| ATC code | N07AX03 |
| PubChem | CID 83898 |
| DrugBank | DB00185 |
| ChemSpider | 75707 |
| UNII | K9V0CDQ56E |
| KEGG | D07667 |
| ChEBI | CHEBI:3568  |
| ChEMBL | CHEMBL1201267 |
| Chemical data | |
| Formula | C10H17NOS |
| Molar mass | 199.31308 g/mol |
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Cevimeline (Evoxac) is a parasympathomimetic and muscarinic agonist,[1] with particular effect on M1 and M3 receptors. It is used in the treatment of dry mouth and especially associated with Sjögren's syndrome.
Mechanism of action[edit]
By activating the M3 receptors of the parasympathetic nervous system, cevimeline stimulates secretion by the salivary glands, thereby alleviating dry mouth.
Side effects[edit]
Known side effects include nausea, vomiting, diarrhea, excessive sweating, rash, headache, runny nose, cough, drowsiness, hot flashes, blurred vision, and difficulty sleeping.[2]
Contraindications include asthma and angle closure glaucoma.[citation needed]
See also[edit]
- Pilocarpine - a similar parasympathomimetic medication for dry mouth (Xerostomia)
- Bethanechol - a similar muscarinic parasympathomimetic with longer lasting effect
References[edit]
- ^ Ono M, Takamura E, Shinozaki K; et al. (July 2004). "Therapeutic effect of cevimeline on dry eye in patients with Sjögren's syndrome: a randomized, double-blind clinical study". Am. J. Ophthalmol. 138 (1): 6–17. doi:10.1016/j.ajo.2004.02.010. PMID 15234277.
- ^ [1] MedicineNet: Cevimeline. Accessed 10/12/2007
