Chlorphenoxamine

Chlorphenoxamine
Systematic (IUPAC) name
	{2-[1-(4-chlorophenyl)-1-phenylethoxy]ethyl}dimethylamine
Clinical data
AHFS/Drugs.com	International Drug Names
Routes of; administration	Oral, topical
Pharmacokinetic data
Bioavailability	Well absorbed
Metabolism	Likely hepatic
Excretion	Renal
Identifiers
CAS Number	77-38-3 562-09-4
ATC code	D04AA34 R06AA06
PubChem	CID 6475
DrugBank	DB09007
ChemSpider	6230
UNII	3UVD77BP8R
KEGG	D07198
ChEMBL	CHEMBL2110774
Chemical data
Formula	C18H22ClNO
Molar mass	303.826 g/mol
	SMILES Clc1ccc(cc1)C(OCCN(C)C)(c2ccccc2)C ;
	InChI InChI=1S/C18H22ClNO/c1-18(21-14-13-20(2)3,15-7-5-4-6-8-15)16-9-11-17(19)12-10-16/h4-12H,13-14H2,1-3H3 ; Key:KKHPNPMTPORSQE-UHFFFAOYSA-N ;
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Chlorphenoxamine (Phenoxene) is an antihistamine and anticholinergic used as an antipruritic^[1] and antiparkinsonian^[2] agent. It is an analog of diphenhydramine.^[3]

References[edit]

^ Bazex, A.; Dupre, A.; Christol, B. (1963). "Trial treatment of urticaria with chlorphenoxamine". Clinique (Paris, France) 58: 447–450. PMID 13967113.
^ Uldall, P. R.; Walton, J. N.; Newell, D. J. (1961). "Chlorphenoxamine hydrochloride in parkinsonism. A controlled trial". British medical journal 1 (5240): 1649–1652. doi:10.1136/bmj.1.5240.1649. PMC 1954253. PMID 13779077.
^ H. Arnold, N. Brock, E. Kuhas, and D. Lorenz, Arzneimittel Forsch., 4, 189 (1954).

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