Tetrindole
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| Systematic (IUPAC) name |
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2,3,3a,4,5,6-Hexahydro-8-cyclohexyl-1H-pyrazino[3,2,1-j,k]carbazole
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| Identifiers |
| ATC code |
None |
| PubChem |
CID 160020 |
| ChemSpider |
140675 Y |
| ChEBI |
CHEBI:77799 N |
| Chemical data |
| Formula |
C20H26N2 |
| Molar mass |
294.43 g/mol |
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C1CCC(CC1)C2=CC3=C(C=C2)N4CCNC5C4=C3CCC5
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InChI=1S/C20H26N2/c1-2-5-14(6-3-1)15-9-10-19-17(13-15)16-7-4-8-18-20(16)22(19)12-11-21-18/h9-10,13-14,18,21H,1-8,11-12H2 Y
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Key:AUXCHYJDVJZEPG-UHFFFAOYSA-N Y
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N Y (what is this?) (verify) |
Tetrindole was a drug candidate that functions by reversibly inhibiting monoamine oxidase A; it was first synthesized in Moscow in the early 1990s.[1] Tetrindole is similar in its chemical structure to pirlindole (Pyrazidol), and metralindole.[2]
References[edit]
- ^ Medvedev, AE; Kirkel, AA; Kamyshanskaya, NS; Moskvitina, TA; Axenova, LN; Gorkin, VZ; Andreeva, NI; Golovina, SM; Mashkovsky, MD (20 January 1994). "Monoamine Oxidase Inhibition by Novel Antidepressant Tetrindole". Biochemical Pharmacology 47 (2): 303–8. doi:10.1016/0006-2952(94)90021-3. PMID 8304974.
- ^ Ramsay, RR; Gravestock, MB (March 2003). "Monoamine Oxidases: to Inhibit or Not to Inhibit". Mini Reviews in Medicinal Chemistry 3 (2): 129–36. PMID 12570845.
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Non-selective
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MAOA-selective
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MAOB-Selective
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