Cinitapride

Cinitapride
Systematic (IUPAC) name
	4-amino-N-[1-(cyclohex-3-en-1-ylmethyl)piperidin-4-yl]-2-ethoxy-5-nitrobenzamide
Clinical data
Trade names	Cintapro, Pemix
Routes of; administration	Oral
Legal status	℞ (Prescription only);
Identifiers
CAS Number	66564-14-5
ATC code	None
PubChem	CID 68867
DrugBank	DB08810
ChemSpider	62099
UNII	R8I97I2L24
KEGG	D07700
ChEMBL	CHEMBL2104523
Chemical data
Formula	C21H30N4O4
Molar mass	402.49 g/mol
Chirality	Racemic mixture
	InChI InChI=1S/C21H30N4O4/c1-2-29-20-13-18(22)19(25(27)28)12-17(20)21(26)23-16-8-10-24(11-9-16)14-15-6-4-3-5-7-15/h3-4,12-13,15-16H,2,5-11,14,22H2,1H3,(H,23,26) ; Key:ZDLBNXXKDMLZMF-UHFFFAOYSA-N ;
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Cinitapride (Cintapro, Pemix) is a gastroprokinetic agent and antiulcer agent of the benzamide class which is marketed in India, Mexico, Pakistan and Spain.^[1]^[2] It acts as an agonist of the 5-HT₁ and 5-HT₄ receptors and as an antagonist of the 5-HT₂ receptors.^[3]^[4]

Uses[edit]

It is indicated for the treatment of gastrointestinal disorders associated with motility disturbances such as gastroesophageal reflux disease, non-ulcer dyspepsia and delayed gastric emptying.

^ Robert M, Salvà M, Segarra R; et al. (July 2007). "The prokinetic cinitapride has no clinically relevant pharmacokinetic interaction and effect on QT during coadministration with ketoconazole". Drug Metabolism and Disposition: the Biological Fate of Chemicals 35 (7): 1149–56. doi:10.1124/dmd.106.010835. PMID 17437965.
^ Fernández AG, Massingham R (January 1985). "Peripheral receptor populations involved in the regulation of gastrointestinal motility and the pharmacological actions of metoclopramide-like drugs". Life Sciences 36 (1): 1–14. doi:10.1016/0024-3205(85)90280-2. PMID 2981378.
^ Alarcón-de-la-Lastra Romero C, López A, Martín MJ, la Casa C, Motilva V (April 1997). "Cinitapride protects against ethanol-induced gastric mucosal injury in rats: role of 5-hydroxytryptamine, prostaglandins and sulfhydryl compounds". Pharmacology 54 (4): 193–202. doi:10.1159/000139487. PMID 9211565.
^ Alarcón de la Lastra C, La Casa C, Martin MJ, Motilva V (March 1998). "Effects of cinitapride on gastric ulceration and secretion in rats". Inflammation Research : Official Journal of the European Histamine Research Society ... [Et Al.] 47 (3): 131–6. doi:10.1007/s000110050301. PMID 9562338.

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