SLC9A6

Solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6
Identifiers
Symbols	SLC9A6 ; MRSA; NHE6
External IDs	OMIM: 300231 MGI: 2443511 HomoloGene: 55971 GeneCards: SLC9A6 Gene
Gene ontology Molecular function • sodium:proton antiporter activity Cellular component • mitochondrion • late endosome • endoplasmic reticulum membrane • plasma membrane • integral component of membrane • dendrite • cytoplasmic vesicle • early endosome membrane • intracellular membrane-bounded organelle • axon terminus • axonal spine • synapse • recycling endosome membrane Biological process • transport • ion transport • regulation of pH • brain-derived neurotrophic factor receptor signaling pathway • sodium ion transmembrane transport • axon extension • neuron projection morphogenesis • synapse organization • regulation of neurotrophin TRK receptor signaling pathway • transmembrane transport • dendritic spine development • dendrite extension • hydrogen ion transmembrane transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10479	236794
Ensembl	ENSG00000198689	ENSMUSG00000060681
UniProt	Q92581	A1L3P4
RefSeq (mRNA)	NM_001042537	NM_172780
RefSeq (protein)	NP_001036002	NP_766368
Location (UCSC)	Chr X: 135.99 – 136.05 Mb	Chr X: 56.61 – 56.66 Mb
PubMed search	[1]	[2]

Sodium/hydrogen exchanger 6 is an integral membrane protein that in humans is encoded by the SLC9A6 gene. It was originally thought to be a mitochondrial-targeted protein, but subsequent studies have localized it to the plasma membrane and recycling endosomes

See also

• SLC9A6 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

Further reading

• Brett CL, Wei Y, Donowitz M, Rao R (May 2002). "Human Na(+)/H(+) exchanger isoform 6 is found in recycling endosomes of cells, not in mitochondria". American Journal of Physiology. Cell Physiology 282 (5): C1031–41. doi:10.1152/ajpcell.00420.2001. PMID 11940519. 
• Cheng J, Moyer BD, Milewski M, Loffing J, Ikeda M, Mickle JE, Cutting GR, Li M, Stanton BA, Guggino WB (Feb 2002). "A Golgi-associated PDZ domain protein modulates cystic fibrosis transmembrane regulator plasma membrane expression". The Journal of Biological Chemistry 277 (5): 3520–9. doi:10.1074/jbc.M110177200. PMID 11707463. 
• Miyazaki E, Sakaguchi M, Wakabayashi S, Shigekawa M, Mihara K (Dec 2001). "NHE6 protein possesses a signal peptide destined for endoplasmic reticulum membrane and localizes in secretory organelles of the cell". The Journal of Biological Chemistry 276 (52): 49221–7. doi:10.1074/jbc.M106267200. PMID 11641397. 
• Numata M, Orlowski J (May 2001). "Molecular cloning and characterization of a novel (Na+,K+)/H+ exchanger localized to the trans-Golgi network". The Journal of Biological Chemistry 276 (20): 17387–94. doi:10.1074/jbc.M101319200. PMID 11279194. 
• Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N (Oct 1996). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Research 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.