Niflumic acid
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| Systematic (IUPAC) name | |
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2-{[3-(trifluoromethyl)phenyl]amino}nicotinic acid
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| Clinical data | |
| AHFS/Drugs.com | International Drug Names |
| Pharmacokinetic data | |
| Biological half-life | 2.5 hr[1] |
| Identifiers | |
| CAS Number | 4394-00-7  |
| ATC code | M01AX02 M02AA17 |
| PubChem | CID 4488 |
| IUPHAR/BPS | 2439 |
| ChemSpider | 4333  |
| UNII | 4U5MP5IUD8 |
| KEGG | D08275 |
| ChEMBL | CHEMBL63323 |
| Chemical data | |
| Formula | C13H9F3N2O2 |
| Molar mass | 282.21797 g/mol |
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| Physical data | |
| Melting point | 204 °C (399 °F) |
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Niflumic acid is a drug used for joint and muscular pain. It is categorized as an inhibitor of cyclooxygenase-2. In experimental biology, it has been employed to inhibit chloride channels.[2] It has also been reported to act on GABA-A[3] and NMDA channels[4] and to block T-type calcium channels.[5]
References[edit]
- ^ "Half life". Drug Bank. Retrieved 15 July 2011.
- ^ Knauf, Philip A.; Mann, Nancy A (1984). "Use of niflumic acid to determine the nature of the asymmetry of the human erythrocyte anion exchange system". J. Gen. Physiol. 83: 703–725. doi:10.1085/jgp.83.5.703. PMC 2215658. PMID 6736917.
- ^ Sinkkonen ST et al. (2003): Receptor subtype-dependent positive and negative modulation of GABA(A) receptor function by niflumic acid, a nonsteroidal anti-inflammatory drug, Mol Pharmacol, p. 753-63. PMID 12920213
- ^ Lerma J., Martin d.R. (1992). "Chloride transport blockers prevent N-methyl-D-aspartate receptor-channel complex activation". Mol. Pharmacol. 41 (2): 217–222. PMID 1371581.
- ^ Balderas E et al. (2012): Niflumic acid blocks native and recombinant T-type channels, J Cell Physiol, p. 2542-55. PMID 21898399
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