Talk:Citicoline
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Contents
ADHD[edit]
Important topic missing. — Preceding unsigned comment added by 174.88.11.188 (talk) 19:56, 1 July 2014 (UTC)
--- The article referenced in relation to citicholine does not say that preliminary research supports use in ADHD. The interview subject says it has been suggested (with no reference to a source) that it could be used to treat ADHD. — Preceding unsigned comment added by 27.99.65.126 (talk) 03:48, 20 March 2016 (UTC)
- A PubMed search on citicoline and attention deficit did not yield any published literature on attention deficit disorders. A search at clinicaltrials.gov did not yield any ongoing research on this topic, either. Based on my and the 2016 comment, removed any mention of ADHD.David notMD (talk) 12:40, 9 March 2017 (UTC)
CDP-choline for patients with multiple sclerosis[edit]
Although funding seems to be the major hurtle in this research project, remyelination could be achieved with CDP-choline (experiments show some benefits). — Preceding unsigned comment added by Don Rosenberger (talk • contribs) 22:18, 18 August 2016 (UTC)
- Reference following explores the theory of CDP-choline for MS, but there are no published clinical trials on this topic. The search site clinicaltrials.gov does not list any ongoing research in this area either.David notMD (talk) 12:34, 9 March 2017 (UTC)
Skripuletz T, Manzel A, et al. Pivotal role of choline metabolites in remyelination. Brain. 2015 Feb;138(Pt 2):398-413.
Vision literature[edit]
As of March 2017, this is what is in the article: "Citicoline improves visual function in patients with glaucoma [18] and may improve amblyopia("lazy eye") when combined with eye patch treatment.[19]" Ref #18 is a review. Ref #19 is a clinical trial. There are no published reviews - the preferred type of reference - for citicoline and amblyopia. The quality of literature is not strong - the cited ref, for example, was not a blinded trial, and some of the trials it cites are quite old. Someone more expert in treatment of amblyopia may decide that it is premature to include citicoline as a treatment.David notMD (talk) 12:59, 6 March 2017 (UTC)
- After asking opinion of more experienced W editor, removed amblyopia mention entirely. The American Academy of Opthamology (2015) refers to this as an emerging treatment concept, with further studies needed.David notMD (talk) 12:14, 9 March 2017 (UTC)
Medical uses - removals and reference upgrades[edit]
Removed mention of citicoline for appetite satiety and improving blood flow, as the references were to one uncontrolled human trial and animal work, respectively. Removed mention of amblyopia because only a few clinical trials, some weak or old, and no good review. Replaced references for glaucoma, memory and stroke with secondary sources (reviews, systemic reviews, meta-analyses).David notMD (talk) 12:28, 9 March 2017 (UTC)