oxamyl (Ref: DPX D1410) ** thioxamyl ** oxamil ** vydate ** dioxamyl ** Translations

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GENERAL INFORMATION
for oxamyl

Description: A soil-applied nematicide and insecticide used to control chewing and sucking insects on field and other crops

Example pests controlled: Aphids; Spider mites; Ticks; Roundworms; Nematodes

Example applications: Field crops; Vegetables; Fruit; Ornamentals

Availability status: Current

Introduction & key dates: 1974, first sold

EC Regulation 1107/2009 (repealing 91/414):

Status	Approved
Dossier rapporteur/co-rapporteur	Ireland
Date inclusion expires	31/01/2018

Approved for use () or known to be used () in the following European countries:

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Australia

General status:

Pesticide type	Insecticide, Acaricide, Nematicide
Substance group	Carbamate
Minimum active substance purity	970 g/kg
Known relevant impurities	EU dossier - None declared
Substance origin	Synthetic
Mode of action	Systemic with contact action. Acetylcholinesterase (AChE) inhibitor.
CAS RN	23135-22-0
EC number	245-445-3
CIPAC number	342
US EPA chemical code	103801
Chiral molecule	No
Chemical formula	C7H13N3O3S
SMILES	O=C(C(=N\OC(=O)NC)\SC)N(C)C
International Chemical Identifier key (InChIKey)	KZAUOCCYDRDERY-UHFFFAOYSA-N
International Chemical Identifier (InChI)	InChI=1S/C7H13N3O3S/c1-8-7(12)13-9-5(14-4)6(11)10(2)3/h1-4H3,(H,8,12)
Structure diagram/image available?	Yes
Molecular mass (g mol-1)	219.26
PIN (Preferred Identification Name)	-
IUPAC name	(EZ)-N,N-dimethyl-2-methylcarbamoyloxyimino-2-(methylthio)acetamide
CAS name	methyl 2-(dimethylamino)-N-[[(methylamino)carbonyl]oxy]-2-oxoethanimidothioate
Other status information	Marine Pollutant
Herbicide Resistance Classification (HRAC)	Not applicable
Herbicide Resistance Classification (WSSA)	Not applicable
Insecticide Resistance Classification (IRAC)	1A
Fungicide Resistance Classification (FRAC)	Not applicable
Examples of recorded resistance	Anthonomus grandis Diglyphus begini Ganaspidium utilis Leptinotarsa decemlineata Lygus lineolaris Phyllonorycter blancardella
Physical state	Colourless or white crystalline powder
Related substances & organisms	cyclohexanone

Formulations:

Property	Value
Example manufacturers & suppliers of products using this active now or historically	DuPont Agchem Access
Example products using this active	Vydate 10G Tevday
UK LERAP status	None
Formulation and application details	Often supplied as granules that are applied directly to the soil before drilling or planting.

ENVIRONMENTAL FATE
for oxamyl

Property	Value	Source/Quality Score/Other Information	Interpretation
Solubility - In water at 20oC (mg l-1)	148100	A5	High
Solubility - In organic solvents at 20oC (mg l-1)	10500	A5 - n-Heptane	-
250000	A5 - Methanol	-
250000	A5 - Acetone	-
41300	A5 - Xylene	-
Melting point (oC)	99.3	A5	-
Boiling point (oC)	-	-	-
Degradation point (oC)	-	-	-
Flashpoint (oC)	-	-	-
Octanol-water partition coefficient at pH 7, 20oC	P	3.63 X 10-01	Calculated	-
Log P	-0.44	A5	Low
Bulk density (g ml-1)/Specific gravity	1.31	A5	-
Dissociation constant (pKa) at 25oC	-2.11	A5	-
Note: Estimated, Very strong acid
Vapour pressure at 25oC (mPa)	0.051	A5	Non-volatile
Henry's law constant at 25oC (Pa m3 mol-1)	4.89 X 10-08	L3	Non-volatile
Henry's law constant at 20oC (dimensionless)	9.80 X 10-09	K3	Non-volatile
GUS leaching potential index	2.29	Calculated	Transition state
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate	Value	1.10 X 10-02	Calculated	-
Note	-
Potential for particle bound transport index	-	Calculated	Low
Maximum UV-vis absorption L mol-1 cm-1	Neutral solution: 290nm = 80.1; [Acidic solution: 290nm = 60.1; [Basic solution: 290nm = 1154	A5	-
Surface tension (mN m-1)	73.1	A5 at 20oC	-

Degradation:

Property	Value	Source/Quality Score/Other Information	Interpretation
Soil degradation (days) (aerobic)	DT50 (typical)	7	A5	Non-persistent
DT50 (lab at 20oC)	6.6	A5	Non-persistent
DT50 (field)	11	A5	Non-persistent
DT90 (lab at 20oC)	22	A5	-
DT90 (field)	36	A5	-
Note	EU dossier lab studies DT50 range 3-11.5 days, DT90 range 9.9-38.2 days aerobic; Field study for UK
Foliar DT50 (days)	Value	0.7	R4	-
Note	Other data sources: DT50=4 days (USDA, F4; EU, A4)
Aqueous photolysis DT50 (days) at pH 7	Value	7.4	A5	Moderately fast
Note	-
Aqueous hydrolysis DT50 (days) at 20oC and pH 7	Value	8	A5	Non-persistent
Note	pH sensitive: stable pH 4 and pH 5, DT50 8 days pH 7, 3 hours at pH 9
Water-sediment DT50 (days)	0.7	A5	Fast
Water phase only DT50 (days)	-	-	-

Soil adsorption and mobility:

Property	Value	Source/Quality Score/Other Information	Interpretation
Linear	Kd	0.194	-	Mobile
Koc	16.6
Notes and range	EU dossier Kd range 0.09-0.44 mL/g, Koc range 8-39 mL/g, Soils=5
Freundlich	Kf	0.18	A5	Mobile
Kfoc	16.0
1/n	1.07
Notes and range	EU dossier kf range 0.05-0.41 mL/g, Kfoc range 8-39 mL/g, 1/n range 0.946-1.27, Soils=4
pH sensitivity	No

Key metabolites:

Metabolite	Formation medium	Estimated maximum occurrence fraction	91/414 relevancy
methyl 2-(dimethylamino)-N-[[(methylamino)carbonyl]oxy]-2-oxoethanimidothioate (Ref: IN-A2213)	Soil	0.510	Major fraction, Relevant
N,N’-dimethyloxamic acid (Ref: IN-D2708)	Soil	0.395	Major fraction, Relevant

Other known metabolites:

Metabolite name and reference	Aliases	Formation medium / Rate	Estimated maximum occurrence fraction	Metabolising enzymes
methyl 2-(dimethylamino)-N-hydroxy-2-oxoethanimidothioate	-	Soil (Anaerobic)	-	-
N,N-dimethyl-1-cyanoformamid (Ref: IN-D0079)	DMCF	Soil; Water/sediment	-	-
(Ref: IN-L2953)	-	Rat	-	-
N,N-dimethylethanediamide (Ref: IN-T2921)	DMEA; DOA	Water/sediment	-	-

ECOTOXICOLOGY
for oxamyl

Property	Value	Source/Quality Score/Other Information	Interpretation
Bio-concentration factor	BCF (l kg-1)	2	P4	Low potential
CT50 (days)	Not available	-
Mammals - Acute oral LD50 (mg kg-1)	2.5	A5 Rat	High
Mammals - Short term dietary NOEL	(mg kg-1)	0.93	A5 Dog, 1 year	High
(ppm diet)	33	-
Birds - Acute LD50 (mg kg-1)	3.16	A5 Anas platyrhynchos	High
Birds - Short term dietary (LC50/LD50)	340 mg kg feed-1	A5 Anas platyrhynchos	-
Fish - Acute 96 hour LC50 (mg l-1)	3.13	A5 Oncorhynchus mykiss	Moderate
Fish - Chronic 21 day NOEC (mg l-1)	0.5	A4 Pimephales promelas, 28 day	Moderate
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1)	0.319	A5 Daphnia magna	Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1)	0.027	A4 Unknown species	Moderate
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1)	-	-	-
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1)	-	-	-
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1)	-	-	-
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1)	-	-	-
Aquatic plants - Acute 7 day EC50, biomass (mg l-1)	-	-	-
Non-target plants	-	-	-
-	-	-
Algae - Acute 72 hour EC50, growth (mg l-1)	0.93	A5 Pseudokirchneriella subcapitata	Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1)	0.5	Q2 Unknown species	Moderate
Honeybees	Contact acute 48 hour LD50 (μg bee-1)	0.26	A5	High
Oral acute 48 hour LD50 (μg bee-1)	0.38	A5	High
Unknown mode acute 48 hour LD50 (μg bee-1)	-	-	-
Earthworms - Acute 14 day LC50 (mg kg-1)	112	A5 Eisenia foetida	Moderate
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1)	-	-	-
Other soil macro-organisms - e.g. Collembola	LR50 / EC50 / NOEC / % Effect	-	-	-
Other arthropod (1)	LR50 g ha-1	0.03	48 hour A5 Aphidius rhopalosiphi	-
% Effect	-	-	-
Other arthropod (2)	LR50 g ha-1	1.8	7 day A5 Typhlodromus pyri	-
% Effect	-	-	-
Soil micro-organisms	Nitrogen mineralisation: No significant adverse effect [Dose: 5 mg kg-1 soil] Carbon mineralisation: No significant adverse effect [Dose: 10 mg kg-1 soil]	A5	-
Mesocosm study data	NOEAEC mg l-1	-	-	-
NOEAEC mg l-1	-	-	-

HUMAN HEALTH AND PROTECTION
for oxamyl

General:

Property	Value	Source/Quality Score/Other Information	Interpretation
Threshold of Toxicological Concern (Cramer Class)	High (class III)	-	-
Mammals - Acute oral LD50 (mg kg-1)	2.5	A5 Rat	High
Mammals - Dermal LD50 (mg kg-1 body weight)	> 2000	A5 Rat	-
Mammals - Inhalation LC50 (mg l-1)	0.056	A5 Rat (nose only)	-
Other Mammal toxicity endpoints	-		-
ADI - Acceptable Daily Intake (mg kg-1bw day-1)	0.001	A5 Rat, SF=100	-
ARfD - Acute Reference Dose (mg kg-1bw day-1)	0.001	A5 Rat, SF=100	-
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1)	0.01	A5 Rat, SF=100	-
Dermal penetration studies (%)	-	-	-
Dangerous Substances Directive 76/464	-	-	-
Exposure Limits	-	-	-
Exposure Routes	Public	No unacceptable risks to bystanders identified
Occupational	Negligible risk to operators
European MRLs	Click here for the EU MRL pesticide database
Drinking Water MAC (μg l-1)	-	-	-

Health issues:

Carcinogen	Mutagen	Endocrine disrupter	Reproduction / development effects	Cholinesterase inhibitor	Neurotoxicant	Respiratory tract irritant	Skin irritant	Eye irritant
		-	-			-
General human health issues	Harmful if ingested

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data

Handling issues:

Property	Value	Source/Quality Score/Other Information	Interpretation
General	Corrosive Not explosive IMDG Transport Code is usually 6.1
CLP classification 2013	Health: H300, H312, H330 Environment: H411
EC Risk Classification	T+ - Very toxic: R26/28 Xn - Harmful: E21 N - Dangerous for the environment: R51, R53
EC Safety Classification	S1/2, S36/37, S45, S61
WHO Classification	Ib	-	Highly hazardous
US EPA Classification (formulation)	I (oral), II (inhalation), IV (dermal, eye)	-	Danger - Highly toxic, Warning - Moderately toxic, Caution - Not acutely toxic
UN Number	Usually 2757
Waste disposal & packaging	Packaging Group II (medium danger)

TRANSLATIONS
for oxamyl

Record last updated: Thursday 11 February 2016
Contact: aeru@herts.ac.uk