Becampanel
From Wikipedia, the free encyclopedia
 |
|
| Systematic (IUPAC) name | |
|---|---|
|
({[(2,3-Dihydroxy-7-nitro-5-quinoxalinyl)methyl]amino}methyl)phosphonic acid
|
|
| Identifiers | |
| CAS Number | 188696-80-2 |
| ATC code | None |
| PubChem | CID 5491960 |
| ChemSpider | 4590791 |
| Chemical data | |
| Formula | C10H11N4O7P |
| Molar mass | 330.191 g/mol |
|
|
|
Becampanel (INN) (code name AMP397) is a quinoxalinedione derivative drug which acts as a competitive antagonist of the AMPA receptor (IC50 = 11 nM).[1][2][3][4] It was investigated as an anticonvulsant for the treatment of epilepsy by Novartis, and was also looked at as a potential treatment for neuropathic pain and cerebral ischemia, but never completed clinical trials.[1][2][3][5]
See also[edit]
References[edit]
- ^ a b John B. Taylor; D. J. Triggle (2007). Comprehensive medicinal chemistry II. Elsevier. p. 290. ISBN 978-0-08-044513-7.
- ^ a b Kwan P, Brodie MJ (September 2007). "Emerging drugs for epilepsy". Expert Opin Emerg Drugs 12 (3): 407–22. doi:10.1517/14728214.12.3.407. PMID 17874969.
- ^ a b Citraro R, Aiello R, Franco V, De Sarro G, Russo E (March 2014). "Targeting α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate receptors in epilepsy". Expert Opin. Ther. Targets 18 (3): 319–34. doi:10.1517/14728222.2014.874416. PMID 24387310.
- ^ World Health Organization (1988). International Nonproprietary Names (INN) for Pharmaceutical Substances. W.H.O.
- ^ Pathan SA, Jain GK, Akhter S, Vohora D, Ahmad FJ, Khar RK (September 2010). "Insights into the novel three 'D's of epilepsy treatment: drugs, delivery systems and devices". Drug Discov. Today 15 (17-18): 717–32. doi:10.1016/j.drudis.2010.06.014. PMID 20603226.
|
 |
This drug article relating to the nervous system is a stub. You can help Wikipedia by expanding it. |
