MMPIP
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| Systematic (IUPAC) name | |
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6-(4-methoxyphenyl)-5-methyl-3-pyridin-4-ylisoxazolo[4,5-c]pyridin-4(5H)-one
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| Chemical data | |
| Formula | C19H19N3O3 |
| Molar mass | 337.372 g/mol |
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MMPIP is a drug used in scientific research that acts as a selective antagonist for the metabotropic glutamate receptor subtype mGluR7.[1] This receptor subtype appears to be involved in the downstream response to cocaine in the brain.[2]
References[edit]
- ^ Suzuki G, Tsukamoto N, Fushiki H, Kawagishi A, Nakamura M, Kurihara H, Mitsuya M, Ohkubo M, Ohta H (October 2007). "In vitro pharmacological characterization of novel isoxazolopyridone derivatives as allosteric metabotropic glutamate receptor 7 antagonists". The Journal of Pharmacology and Experimental Therapeutics 323 (1): 147–56. doi:10.1124/jpet.107.124701. PMID 17609420.
- ^ Li X, Li J, Peng XQ, Spiller K, Gardner EL, Xi ZX (June 2009). "Metabotropic glutamate receptor 7 modulates the rewarding effects of cocaine in rats: involvement of a ventral pallidal GABAergic mechanism". Neuropsychopharmacology 34 (7): 1783–96. doi:10.1038/npp.2008.236. PMID 19158667.
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