GBR-13098
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| Names | |
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| IUPAC name
1-{2-[Bis(4-fluorophenyl)methoxy]ethyl}-4-[3-(4-fluorophenyl)propyl]piperazine
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| Identifiers | |
| ChemSpider | 117130 |
| Jmol 3D image | Interactive graph |
| PubChem | 132673 |
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| Properties | |
| C28H31F3N2O | |
| Molar mass | 468.56 g·mol−1 |
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Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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| Infobox references | |
GBR-13098 is a psychostimulant and selective dopamine uptake inhibitor.[1]
Blocking the endogenous striatal dopamine (DA) transporter with GBR-13098 in mice has been shown to prevent damage to the DA nerve terminals caused by malonate. It was suggested that DA transporter inhibitors like GBR-13098 could be used to prevent or treat neurodegenerative disorders caused by the effect of mitochondrial dysfunction on DA homeostasis.[2]
See also[edit]
References[edit]
- ^ Pileblad E, and Engberg G. (Dec 1986). "GBR 13098, a selective dopamine uptake inhibitor; behavioural, biochemical and electrophysiological studies.". Naunyn Schmiedebergs Arch Pharmacol. 334 (4): 383–7. PMID 2950328.
- ^ Moy LY; et al. (Feb 2007). "Mitochondrial stress-induced dopamine efflux and neuronal damage by malonate involves the dopamine transporter.". J Pharmacol Exp Ther. 320 (2): 747–56. doi:10.1124/jpet.106.110791.
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