Thiothixene

Thiothixene
Systematic (IUPAC) name
	(9Z)-N,N-dimethyl-9-[3-(4-methylpiperazin-1-yl)propylidene]-9H-thioxanthene-2-sulfonamide
Clinical data
Trade names	Navane
AHFS/Drugs.com	monograph
MedlinePlus	a682867
Routes of; administration	Oral
Legal status	℞ (Prescription only);
Pharmacokinetic data
Metabolism	Hepatic
Biological half-life	10-20 hours
Identifiers
CAS Number	5591-45-7
ATC code	N05AF04
PubChem	CID 941651
IUPHAR/BPS	212
DrugBank	DB01623
ChemSpider	819430
UNII	7318FJ13YJ
ChEMBL	CHEMBL1201
Chemical data
Formula	C23H29N3O2S2
Molar mass	443.627 g/mol
	SMILES O=S(=O)(N(C)C)c2cc1C(\c3c(Sc1cc2)cccc3)=C/CCN4CCN(C)CC4 ;
	InChI InChI=1S/C23H29N3O2S2/c1-24(2)30(27,28)18-10-11-23-21(17-18)19(20-7-4-5-9-22(20)29-23)8-6-12-26-15-13-25(3)14-16-26/h4-5,7-11,17H,6,12-16H2,1-3H3/b19-8- ; Key:GFBKORZTTCHDGY-UWVJOHFNSA-N ;
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Tiotixene (INN) or Thiothixene (USAN; Navane) is a typical antipsychotic drug of the thioxanthene class used in the treatment of psychoses like schizophrenia. It was introduced on July 24, 1967^[1] by Pfizer.^[2]

References[edit]

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Systematic (IUPAC) name

(9Z)-N,N-dimethyl-9-[3-(4-methylpiperazin-1-yl)propylidene]-9H-thioxanthene-2-sulfonamide
Clinical data
Trade names	Navane
AHFS/Drugs.com	monograph
MedlinePlus	a682867
Routes of administration	Oral
Legal status	℞ (Prescription only)
Pharmacokinetic data
Metabolism	Hepatic
Biological half-life	10-20 hours
Identifiers
CAS Number	5591-45-7^Y
ATC code	N05AF04
PubChem	CID 941651
IUPHAR/BPS	212
DrugBank	DB01623^Y
ChemSpider	819430^Y
UNII	7318FJ13YJ^Y
ChEMBL	CHEMBL1201^Y
Chemical data
Formula	C₂₃H₂₉N₃O₂S₂
Molar mass	443.627 g/mol
SMILES O=S(=O)(N(C)C)c2cc1C(\c3c(Sc1cc2)cccc3)=C/CCN4CCN(C)CC4
InChI InChI=1S/C23H29N3O2S2/c1-24(2)30(27,28)18-10-11-23-21(17-18)19(20-7-4-5-9-22(20)29-23)8-6-12-26-15-13-25(3)14-16-26/h4-5,7-11,17H,6,12-16H2,1-3H3/b19-8-^Y Key:GFBKORZTTCHDGY-UWVJOHFNSA-N^Y
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