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Title:
Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway
Authors:
Yamamoto, Masahiro; Sato, Shintaro; Hemmi, Hiroaki; Hoshino, Katsuaki; Kaisho, Tsuneyasu; Sanjo, Hideki; Takeuchi, Osamu; Sugiyama, Masanaka; Okabe, Masaru; Takeda, Kiyoshi; Akira, Shizuo
Affiliation:
AA(Department of Host Defense, Research Institute for Microbial Diseases, Osaka University,), AB(Department of Host Defense, Research Institute for Microbial Diseases, Osaka University,; ERATO, Japan Science and Technology Corporation,), AC(Department of Host Defense, Research Institute for Microbial Diseases, Osaka University,), AD(Department of Host Defense, Research Institute for Microbial Diseases, Osaka University,; RIKEN Research Center for Allergy and Immunology, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan), AE(Department of Host Defense, Research Institute for Microbial Diseases, Osaka University,; RIKEN Research Center for Allergy and Immunology, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan), AF(Department of Host Defense, Research Institute for Microbial Diseases, Osaka University,), AG(Department of Host Defense, Research Institute for Microbial Diseases, Osaka University,), AH(Department of Host Defense, Research Institute for Microbial Diseases, Osaka University,), AI(Genome Information Research Center, 3-1 Yamada-oka, Suita Osaka 565-0871, Japan.), AJ(Department of Host Defense, Research Institute for Microbial Diseases, Osaka University,; ERATO, Japan Science and Technology Corporation,), AK(Department of Host Defense, Research Institute for Microbial Diseases, Osaka University,; ERATO, Japan Science and Technology Corporation,)
Publication:
Science, Volume 301, Issue 5633, pp. 640-643 (2003). (Sci Homepage)
Publication Date:
08/2003
Category:
IMMUNOLOGY
Origin:
SCIENCE
Abstract Copyright:
(c) 2003: Science
DOI:
10.1126/science.1087262
Bibliographic Code:
2003Sci...301..640Y

Abstract

Stimulation of Toll-like receptors (TLRs) triggers activation of a common MyD88-dependent signaling pathway as well as a MyD88-independent pathway that is unique to TLR3 and TLR4 signaling pathways leading to interferon (IFN)-β production. Here we disrupted the gene encoding a Toll/IL-1 receptor (TIR) domain-containing adaptor, TRIF. TRIF-deficient mice were defective in both TLR3- and TLR4-mediated expression of IFN-β and activation of IRF-3. Furthermore, inflammatory cytokine production in response to the TLR4 ligand, but not to other TLR ligands, was severely impaired in TRIF-deficient macrophages. Mice deficient in both MyD88 and TRIF showed complete loss of nuclear factor kappa B activation in response to TLR4 stimulation. These findings demonstrate that TRIF is essential for TLR3- and TLR4-mediated signaling pathways facilitating mammalian antiviral host defense.
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