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J Med Ethics. 2005 Sep; 31(9): 526–530.
PMCID: PMC1734214
PMID: 16131554

Firing up the nature/nurture controversy: bioethics and genetic determinism

I de Melo-Martin
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Selected References

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  • KLISIECKI A, WIKTOR Z, PYTASZ M, DEC L. [Alkalization, ammonia and urea in urine in kidney diseases]. Pol Tyg Lek. 1961 Dec 25;16:2001–2004. [PubMed]
  • Verhey Allen D. Cloning: revisiting an old debate. Kennedy Inst Ethics J. 1994 Sep;4(3):227–234. [PubMed]
  • Juengst ET. Can enhancement be distinguished from prevention in genetic medicine? J Med Philos. 1997 Apr;22(2):125–142. [PubMed]
  • Rhodes R. Genetic links, family ties, and social bonds: rights and responsibilities in the face of genetic knowledge. J Med Philos. 1998 Feb;23(1):10–30. [PubMed]
  • Robertson S, Savulescu J. Is there a case in favour of predictive genetic testing in young children? Bioethics. 2001 Feb;15(1):26–49. [PubMed]
  • Ross LF, Moon MR. Ethical issues in genetic testing of children. Arch Pediatr Adolesc Med. 2000 Sep;154(9):873–879. [PubMed]
  • Cohen Cynthia B. Wrestling with the future: should we test children for adult-onset genetic conditions? Kennedy Inst Ethics J. 1998 Jun;8(2):111–130. [PubMed]
  • MacDonald Marcy E, Gines Silvia, Gusella James F, Wheeler Vanessa C. Huntington's disease. Neuromolecular Med. 2003;4(1-2):7–20. [PubMed]
  • Ho LW, Carmichael J, Swartz J, Wyttenbach A, Rankin J, Rubinsztein DC. The molecular biology of Huntington's disease. Psychol Med. 2001 Jan;31(1):3–14. [PubMed]
  • Davies S, Ramsden DB. Huntington's disease. Mol Pathol. 2001 Dec;54(6):409–413. [PMC free article] [PubMed]
  • Wellington CL, Brinkman RR, O'Kusky JR, Hayden MR. Toward understanding the molecular pathology of Huntington's disease. Brain Pathol. 1997 Jul;7(3):979–1002. [PubMed]
  • Holzmann C, Schmidt T, Thiel G, Epplen JT, Riess O. Functional characterization of the human Huntington's disease gene promoter. Brain Res Mol Brain Res. 2001 Aug 15;92(1-2):85–97. [PubMed]
  • Dürr A, Dodé C, Hahn V, Pêcheux C, Pillon B, Feingold J, Kaplan JC, Agid Y, Brice A. Diagnosis of "sporadic" Huntington's disease. J Neurol Sci. 1995 Mar;129(1):51–55. [PubMed]
  • Risch N. Molecular epidemiology of Tay-Sachs disease. Adv Genet. 2001;44:233–252. [PubMed]
  • Rozenberg R, Pereira L da V. The frequency of Tay-Sachs disease causing mutations in the Brazilian Jewish population justifies a carrier screening program. Sao Paulo Med J. 2001 Jul 5;119(4):146–149. [PubMed]
  • Peleg L, Karpati M, Gazit E, Raas-Rothschild A, Goldman B. Mutations of the hexosaminidase A gene in Ashkenazi and non-Ashkenazi Jews. Biochem Med Metab Biol. 1994 Jun;52(1):22–26. [PubMed]
  • Yamanaka S, Johnson ON, Norflus F, Boles DJ, Proia RL. Structure and expression of the mouse beta-hexosaminidase genes, Hexa and Hexb. Genomics. 1994 Jun;21(3):588–596. [PubMed]
  • Sutton V Reid. Tay-Sachs disease screening and counseling families at risk for metabolic disease. Obstet Gynecol Clin North Am. 2002 Jun;29(2):287–296. [PubMed]
  • Zinberg RE, Kornreich R, Edelmann L, Desnick RJ. Prenatal genetic screening in the Ashkenazi Jewish population. Clin Perinatol. 2001 Jun;28(2):367–382. [PubMed]
  • Petersen GM, Rotter JI, Cantor RM, Field LL, Greenwald S, Lim JS, Roy C, Schoenfeld V, Lowden JA, Kaback MM. The Tay-Sachs disease gene in North American Jewish populations: geographic variations and origin. Am J Hum Genet. 1983 Nov;35(6):1258–1269. [PMC free article] [PubMed]
  • Risch NJ. Searching for genetic determinants in the new millennium. Nature. 2000 Jun 15;405(6788):847–856. [PubMed]
  • Dennis Carina. Epigenetics and disease: Altered states. Nature. 2003 Feb 13;421(6924):686–688. [PubMed]
  • Vineis P, Schulte P, McMichael AJ. Misconceptions about the use of genetic tests in populations. Lancet. 2001 Mar 3;357(9257):709–712. [PubMed]
  • Dipple KM, McCabe ER. Phenotypes of patients with "simple" Mendelian disorders are complex traits: thresholds, modifiers, and systems dynamics. Am J Hum Genet. 2000 Jun;66(6):1729–1735. [PMC free article] [PubMed]
  • Mickle JE, Cutting GR. Genotype-phenotype relationships in cystic fibrosis. Med Clin North Am. 2000 May;84(3):597–607. [PubMed]
  • Scriver CR, Waters PJ. Monogenic traits are not simple: lessons from phenylketonuria. Trends Genet. 1999 Jul;15(7):267–272. [PubMed]
  • Senior V, Marteau TM, Peters TJ. Will genetic testing for predisposition for disease result in fatalism? A qualitative study of parents responses to neonatal screening for familial hypercholesterolaemia. Soc Sci Med. 1999 Jun;48(12):1857–1860. [PubMed]
  • Wachbroit Robert. The question not asked: the challenge of pleiotropic genetic tests. Kennedy Inst Ethics J. 1998 Jun;8(2):131–144. [PubMed]
  • Khabele Dineo, Runowicz Carolyn D. Genetic counseling, testing, and screening for breast and ovarian cancer: practical and social considerations. Curr Womens Health Rep. 2002 Jun;2(3):163–169. [PubMed]
  • Coughlin SS, Khoury MJ, Steinberg KK. BRCA1 and BRCA2 gene mutations and risk of breast cancer. Public health perspectives. Am J Prev Med. 1999 Feb;16(2):91–98. [PubMed]
  • Weitzel JN. The current social, political, and medical role of genetic testing in familial breast and ovarian carcinomas. Curr Opin Obstet Gynecol. 1999 Feb;11(1):65–70. [PubMed]
  • Garber J. A 40-year-old woman with a strong family history of breast cancer. JAMA. 1999 Nov 24;282(20):1953–1960. [PubMed]
  • Hopper JL, Southey MC, Dite GS, Jolley DJ, Giles GG, McCredie MR, Easton DF, Venter DJ. Population-based estimate of the average age-specific cumulative risk of breast cancer for a defined set of protein-truncating mutations in BRCA1 and BRCA2. Australian Breast Cancer Family Study. Cancer Epidemiol Biomarkers Prev. 1999 Sep;8(9):741–747. [PubMed]
  • Ford D, Easton DF, Stratton M, Narod S, Goldgar D, Devilee P, Bishop DT, Weber B, Lenoir G, Chang-Claude J, et al. Genetic heterogeneity and penetrance analysis of the BRCA1 and BRCA2 genes in breast cancer families. The Breast Cancer Linkage Consortium. Am J Hum Genet. 1998 Mar;62(3):676–689. [PMC free article] [PubMed]
  • Collins FS. BRCA1--lots of mutations, lots of dilemmas. N Engl J Med. 1996 Jan 18;334(3):186–188. [PubMed]
  • Daw EW, Payami H, Nemens EJ, Nochlin D, Bird TD, Schellenberg GD, Wijsman EM. The number of trait loci in late-onset Alzheimer disease. Am J Hum Genet. 2000 Jan;66(1):196–204. [PMC free article] [PubMed]
  • Farrer LA, Cupples LA, Haines JL, Hyman B, Kukull WA, Mayeux R, Myers RH, Pericak-Vance MA, Risch N, van Duijn CM. Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium. JAMA. 1997 Oct 22;278(16):1349–1356. [PubMed]
  • Post SG, Whitehouse PJ, Binstock RH, Bird TD, Eckert SK, Farrer LA, Fleck LM, Gaines AD, Juengst ET, Karlinsky H, et al. The clinical introduction of genetic testing for Alzheimer disease. An ethical perspective. JAMA. 1997 Mar 12;277(10):832–836. [PubMed]
  • Bird TD, Levy-Lahad E, Poorkaj P, Sharma V, Nemens E, Lahad A, Lampe TH, Schellenberg GD. Wide range in age of onset for chromosome 1--related familial Alzheimer's disease. Ann Neurol. 1996 Dec;40(6):932–936. [PubMed]
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