AM-087
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| Systematic (IUPAC) name | |
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(6aR,10aR)-3-(2-methyl-6-bromohex-2-yl)-6,6,9-trimethyl-6a,7,10,10a-tetrahydrobenzo[c]chromen-1-ol
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| Identifiers | |
| PubChem | CID: 10717065 |
| ChemSpider | 8892405  |
| ChEMBL | CHEMBL199561 |
| Chemical data | |
| Formula | C23H33BrO2 |
| Molecular mass | 421.410 g/mol |
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AM-087 is an analgesic drug that is a cannabinoid agonist. It is a derivative of Δ8THC substituted on the 3-position side chain. AM-087 is a potent CB1 agonist with a Ki of 0.43nM, making it around 100x more potent than THC itself. This is most likely due to the bulky bromine substituent on the side chain.[1][2][3]
See also[edit]
References[edit]
- ^ Charalambous A, et al. Pharmacological evaluation of halogenated delta 8-THC analogs. Pharmacology, Biochemistry and Behaviour. 1991 Nov;40(3):509-12. PMID 1666915
- ^ Nikas SP, et al. The role of halogen substitution in classical cannabinoids: a CB1 pharmacophore model. AAPS Journal. 2004 Oct 19;6(4):e30. PMID 15760095
- ^ Roger Pertwee. Cannabinoids. Handbook of Experimental Pharmacology Volume 168, p 269. Springer. ISBN 3-540-22565-X
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