Thozalinone
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| Systematic (IUPAC) name | |
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(RS)-2-(Dimethylamino)-5-phenyl-1,3-oxazol-4(5H)-one
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Oral |
| Identifiers | |
| CAS Number | 655-05-0 |
| ATC code | None |
| PubChem | CID: 12602 |
| ChemSpider | 12082  |
| UNII | 68X5932947 |
| KEGG | D06115 |
| Synonyms | Tozalinone, Thozalinon |
| Chemical data | |
| Formula | C11H12N2O2 |
| Molecular mass | 204.225 g/mol |
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Thozalinone (USAN) (brand name Stimsen; former developmental code name CL-39808) is a psychostimulant that has been used as an antidepressant in Europe.[1][2][3][4][5] It has also been trialed as an anorectic.[6] Thozalinone is described as a "dopaminergic stimulant",[7] and likely acts via inducing the release of dopamine and norepinephrine similarly to its analogues pemoline and aminorex.[2][8][9]
See also[edit]
References[edit]
- ^ J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 435–. ISBN 978-1-4757-2085-3.
- ^ a b Greenblatt EN, Osterberg AC (July 1965). "Some pharmacologic properties of thozalinone, a new excitant". Toxicology and Applied Pharmacology 7 (4): 566–78. doi:10.1016/0041-008X(65)90042-6. PMID 4378772.
- ^ Dictionary of organic compounds. London: Chapman & Hall. 1996. ISBN 0-412-54090-8.
- ^ Merck index on CD-ROM: Windows. London: Chapman & Hall EPD. 1998. ISBN 0-412-82910-X.
- ^ Gallant DM, Bishop MP, Scrignar CB, Hornsby L, Moore B, Inturrisi BB (December 1966). "A double-blind study of thozalinone (C1 39,808) in depressed outpatients". Current Therapeutic Research, Clinical and Experimental 8 (12): 621–2. PMID 4962734.
- ^ Leite AC, Liepen LL, Costa VP (September 1971). "[Clinical trial of Stimsem Thozalinone in the treatment of obese patients]". Revista Brasileira De Medicina (in Portuguese) 28 (9): 475–8. PMID 5139648.
- ^ Yen-koo, H. C.; Balazs, T. (2015). "Detection of Dopaminergic Supersensitivity Induced by Neuroleptic Drugs in Mice". Drug and Chemical Toxicology 3 (2): 237–247. doi:10.3109/01480548009108286. ISSN 0148-0545.
- ^ Yen-Koo HC, Balazs T (1980). "Detection of dopaminergic supersensitivity induced by neuroleptic drugs in mice". Drug and Chemical Toxicology 3 (2): 237–47. doi:10.3109/01480548009108286. PMID 6112126.
- ^ Yen-Koo HC, Davis DA, Balazs T (1985). "Inhibition of dopaminergic agonist-induced gnawing behavior by neuroleptic drugs in mice". Drug and Chemical Toxicology 8 (6): 495–502. doi:10.3109/01480548509041072. PMID 2868876.
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