NEFA (drug)
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| Systematic (IUPAC) name | |
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(4aR,9aS)-N-Ethyl-4,4a,9,9a-tetrahydro-1H-fluoren-4a-amine
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| Chemical data | |
| Formula | C15H19N |
| Molar mass | 213.3181 g/mol |
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NEFA is a moderate affinity NMDA antagonist (IC50 = 0.51 μM). It is a structural analog of phencyclidine.[1] It was first synthesized by a team at Parke Davis in the late 1950s.[2]
References[edit]
- ^ Dilmore JG, Johnson JW (1998). "Open channel block and alteration of N-methyl-D-aspartic acid receptor gating by an analog of phencyclidine". Biophysical Journal 75 (4): 1801–16. doi:10.1016/S0006-3495(98)77622-2. PMC 1299852. PMID 9746522.
- ^ GB Patent 893920 - Polycyclic amino compounds and methods for their production
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