GPR144
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| Adhesion G protein-coupled receptor D2 | ||||||||
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| Identifiers | ||||||||
| Symbols | ADGRD2 ; GPR144; PGR24 | |||||||
| External IDs | HomoloGene: 130029 IUPHAR: GeneCards: ADGRD2 Gene | |||||||
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| RNA expression pattern | ||||||||
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| More reference expression data | ||||||||
| Orthologs | ||||||||
| Species | Human | Mouse | ||||||
| Entrez | 347088 | n/a | ||||||
| Ensembl | ENSG00000180264 | n/a | ||||||
| UniProt | Q7Z7M1 | n/a | ||||||
| RefSeq (mRNA) | NM_001161808 | n/a | ||||||
| RefSeq (protein) | NP_001155280 | n/a | ||||||
| Location (UCSC) | Chr 9: 127.21 – 127.24 Mb |
n/a | ||||||
| PubMed search | [1] | n/a | ||||||
Probable G-protein coupled receptor 144 is a protein that in humans is encoded by the GPR144 gene.[1][2] This gene encodes a member of the adhesion-GPCR family of receptors. Family members are characterised by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.[3][4]
References[edit]
- ^ "Entrez Gene: GPR144 G protein-coupled receptor 144".
- ^ Fredriksson R, Lagerstrom MC, Hoglund PJ, Schioth HB (Nov 2002). "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions". FEBS Lett 531 (3): 407–14. doi:10.1016/S0014-5793(02)03574-3. PMID 12435584.
- ^ Stacey M, Yona S (2011). AdhesionGPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 1-4419-7912-3.
- ^ Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT (March 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". EMBO J. 31 (6): 1364–78. doi:10.1038/emboj.2012.26. PMC 3321182. PMID 22333914.
Further reading[edit]
- Vassilatis DK, Hohmann JG, Zeng H; et al. (2003). "The G protein-coupled receptor repertoires of human and mouse.". Proc. Natl. Acad. Sci. U.S.A. 100 (8): 4903–8. doi:10.1073/pnas.0230374100. PMC 153653. PMID 12679517.
- Humphray SJ, Oliver K, Hunt AR; et al. (2004). "DNA sequence and analysis of human chromosome 9.". Nature 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
- Bjarnadóttir TK, Fredriksson R, Höglund PJ; et al. (2005). "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors.". Genomics 84 (1): 23–33. doi:10.1016/j.ygeno.2003.12.004. PMID 15203201.
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