GPR32
| G protein-coupled receptor 32 | ||||||||
|---|---|---|---|---|---|---|---|---|
| Identifiers | ||||||||
| Symbols | GPR32 ; RVDR1 | |||||||
| External IDs | OMIM: 603195 HomoloGene: 88647 IUPHAR: 99 GeneCards: GPR32 Gene | |||||||
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| RNA expression pattern | ||||||||
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| More reference expression data | ||||||||
| Orthologs | ||||||||
| Species | Human | Mouse | ||||||
| Entrez | 2854 | n/a | ||||||
| Ensembl | ENSG00000142511 | n/a | ||||||
| UniProt | O75388 | n/a | ||||||
| RefSeq (mRNA) | NM_001506 | n/a | ||||||
| RefSeq (protein) | NP_001497 | n/a | ||||||
| Location (UCSC) | Chr 19: 50.77 – 50.77 Mb |
n/a | ||||||
| PubMed search | [1] | n/a | ||||||
G protein-coupled receptor 32, also known as GPR32 or the RvD1 receptor, is a human gene belonging to the rhodopsin-like subfamily of G protein-coupled receptors.[1] GPR32 is most closely related to the chemotaxic formyl peptide receptors.[2]
At least 5 members of the D series of resolvins (RvDs) viz., RvD1, AT-RVD1, RvD3, AT-RvD3, and RvD5, activate their target cells through this receptor; these results have lead to naming GPR32 the RVD1 receptor (see Resolvin#Mechanisms of Action).[3][4][5] RvDs are metabolites of the omega-3 fatty acid, docosahexaenoic acid, that are implicated as contributing to the inhibition and resolution of a diverse range of inflammation and inflammation-related responses as well as in the healing of healing of these inflammatory lesions in animals and humans (see Resolvin).
References[edit]
- ^ "Entrez Gene: GPR32 G protein-coupled receptor 32".
- ^ Marchese A, Nguyen T, Malik P, Xu S, Cheng R, Xie Z, Heng HH, George SR, Kolakowski LF, O'Dowd BF (1998). "Cloning genes encoding receptors related to chemoattractant receptors". Genomics 50 (2): 281–6. doi:10.1006/geno.1998.5297. PMID 9653656.
- ^ Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1660-5. doi: 10.1073/pnas.0907342107. Epub 2010 Jan 4.
- ^ Cold Spring Harb Perspect Biol. 2014 Oct 30;7(2):a016311. doi: 10.1101/cshperspect.a016311. Review.PMID: 25359497
- ^ Am J Physiol Lung Cell Mol Physiol. 2015 May 1;308(9):L904-11. doi: 10.1152/ajplung.00370.2014. Epub 2015 Mar 13.
Further reading[edit]
- Marchese A, Nguyen T, Malik P, et al. (1998). "Cloning genes encoding receptors related to chemoattractant receptors.". Genomics 50 (2): 281–6. doi:10.1006/geno.1998.5297. PMID 9653656.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
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