TAS2R1
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| Taste receptor, type 2, member 1 | ||||||||
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| Identifiers | ||||||||
| Symbols | TAS2R1 ; T2R1; TRB7 | |||||||
| External IDs | OMIM: 604796 MGI: 2681253 HomoloGene: 10480 IUPHAR: 659 GeneCards: TAS2R1 Gene | |||||||
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| RNA expression pattern | ||||||||
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| More reference expression data | ||||||||
| Orthologs | ||||||||
| Species | Human | Mouse | ||||||
| Entrez | 50834 | 57254 | ||||||
| Ensembl | ENSG00000169777 | ENSMUSG00000045267 | ||||||
| UniProt | Q9NYW7 | Q9JKT2 | ||||||
| RefSeq (mRNA) | NM_019599 | NM_020503 | ||||||
| RefSeq (protein) | NP_062545 | NP_065249 | ||||||
| Location (UCSC) | Chr 5: 9.63 – 9.71 Mb |
Chr 15: 32.18 – 32.18 Mb |
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| PubMed search | [1] | [2] | ||||||
Taste receptor type 2 member 1 is a protein that in humans is encoded by the TAS2R1 gene.[1][2][3]
Function[edit]
This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. This intronless taste receptor gene encodes a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is mapped to chromosome 5p15, the location of a genetic locus (PROP) that controls the detection of the bitter compound 6-n-propyl-2-thiouracil.[3]
See also[edit]
References[edit]
- ^ Adler E, Hoon MA, Mueller KL, Chandrashekar J, Ryba NJ, Zuker CS (Apr 2000). "A novel family of mammalian taste receptors". Cell 100 (6): 693–702. doi:10.1016/S0092-8674(00)80705-9. PMID 10761934.
- ^ Matsunami H, Montmayeur JP, Buck LB (Apr 2000). "A family of candidate taste receptors in human and mouse". Nature 404 (6778): 601–4. doi:10.1038/35007072. PMID 10766242.
- ^ a b "Entrez Gene: TAS2R1 taste receptor, type 2, member 1".
Further reading[edit]
- Kinnamon SC (2000). "A plethora of taste receptors". Neuron 25 (3): 507–10. doi:10.1016/S0896-6273(00)81054-5. PMID 10774719.
- Margolskee RF (2002). "Molecular mechanisms of bitter and sweet taste transduction". J. Biol. Chem. 277 (1): 1–4. doi:10.1074/jbc.R100054200. PMID 11696554.
- Montmayeur JP, Matsunami H (2002). "Receptors for bitter and sweet taste". Curr. Opin. Neurobiol. 12 (4): 366–71. doi:10.1016/S0959-4388(02)00345-8. PMID 12139982.
- Chandrashekar J, Mueller KL, Hoon MA, Adler E, Feng L, Guo W, Zuker CS, Ryba NJ (2000). "T2Rs function as bitter taste receptors". Cell 100 (6): 703–11. doi:10.1016/S0092-8674(00)80706-0. PMID 10761935.
- Firestein S (2000). "The good taste of genomics". Nature 404 (6778): 552–3. doi:10.1038/35007167. PMID 10766221.
- Zhang Y, Hoon MA, Chandrashekar J, Mueller KL, Cook B, Wu D, Zuker CS, Ryba NJ (2003). "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways". Cell 112 (3): 293–301. doi:10.1016/S0092-8674(03)00071-0. PMID 12581520.
- Fischer A, Gilad Y, Man O, Pääbo S (2005). "Evolution of bitter taste receptors in humans and apes". Mol. Biol. Evol. 22 (3): 432–6. doi:10.1093/molbev/msi027. PMID 15496549.
- Go Y, Satta Y, Takenaka O, Takahata N (2006). "Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates". Genetics 170 (1): 313–26. doi:10.1534/genetics.104.037523. PMC 1449719. PMID 15744053.
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