CLEC10A
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| Aliases | CLEC10A, CD301, CLECSF13, CLECSF14, HML, HML2, MGL, C-type lectin domain family 10 member A | |||||||
| External IDs | MGI: 96975 HomoloGene: 7836 GeneCards: 10462 | |||||||
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| Species | Human | Mouse | ||||||
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| Location (UCSC) | Chr 17: 7.07 – 7.08 Mb | Chr 11: 70.16 – 70.17 Mb | ||||||
| PubMed search | [1] | [2] | ||||||
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| View/Edit Human | View/Edit Mouse |
C-type lectin domain family 10 member A also known as CLEC10A is a protein that in humans is encoded by the CLEC10A gene.[1]
Function[edit]
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may function as a cell surface antigen. Two transcript variants encoding distinct isoforms have been identified for this gene.[2]
References[edit]
- ^ Suzuki N, Yamamoto K, Toyoshima S, Osawa T, Irimura T (January 1996). "Molecular cloning and expression of cDNA encoding human macrophage C-type lectin. Its unique carbohydrate binding specificity for Tn antigen". J. Immunol. 156 (1): 128–35. PMID 8598452.
- ^ "Entrez Gene: CLEC10A C-type lectin domain family 10, member A".
Further reading[edit]
- Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- van Vliet SJ, Steeghs L, Bruijns SC, et al. (2009). Seifert HS, ed. "Variation of Neisseria gonorrhoeae Lipooligosaccharide Directs Dendritic Cell–Induced T Helper Responses". PLoS Pathog. 5 (10): e1000625. doi:10.1371/journal.ppat.1000625. PMC 2757725. PMID 19834553.
- Iijima M, Tomita M, Morozumi S, et al. (2009). "Single nucleotide polymorphism of TAG-1 influences IVIg responsiveness of Japanese patients with CIDP". Neurology 73 (17): 1348–52. doi:10.1212/WNL.0b013e3181bd1139. PMID 19776380.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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