Galanin receptor 3

Galanin receptor 3
Identifiers
Symbol	GALR3
External IDs	OMIM: 603692 MGI: 1329003 HomoloGene: 20798 IUPHAR: 245 ChEMBL: 2731 GeneCards: GALR3 Gene
Gene ontology Molecular function • galanin receptor activity • peptide hormone binding Cellular component • plasma membrane • integral component of plasma membrane • integral component of membrane Biological process • adenylate cyclase-modulating G-protein coupled receptor signaling pathway • negative regulation of adenylate cyclase activity • phospholipase C-activating G-protein coupled receptor signaling pathway • neuropeptide signaling pathway • synaptic transmission • learning or memory • feeding behavior • positive regulation of transcription from RNA polymerase II promoter Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8484	14429
Ensembl	ENSG00000128310	ENSMUSG00000006378
UniProt	O60755	O88853
RefSeq (mRNA)	NM_003614	NM_015738
RefSeq (protein)	NP_003605	NP_056553
Location (UCSC)	Chr 22: 37.82 – 37.83 Mb	Chr 15: 79.03 – 79.04 Mb
PubMed search	[1]	[2]

Galanin receptor 3 (GAL₃) is a G-protein coupled receptor encoded by the GALR3 gene.

The neuropeptide galanin modulates a variety of physiologic processes including cognition/memory, sensory/pain processing, hormone secretion, and feeding behavior. The human galanin receptors are G protein-coupled receptors that functionally couple to their intracellular effector through distinct signaling pathways. GALR3 is found in many tissues and may be expressed as 1.4-, 2.4-, and 5-kb transcripts

See also

• Galanin receptor

External links

• "Galanin Receptors: GAL₃". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading

• Smith KE, Walker MW, Artymyshyn R, et al. (1998). "Cloned human and rat galanin GALR3 receptors. Pharmacology and activation of G-protein inwardly rectifying K+ channels". J. Biol. Chem. 273 (36): 23321–6. doi:10.1074/jbc.273.36.23321. PMID 9722565. 
• Kolakowski LF, O'Neill GP, Howard AD, et al. (1998). "Molecular characterization and expression of cloned human galanin receptors GALR2 and GALR3". J. Neurochem. 71 (6): 2239–51. doi:10.1046/j.1471-4159.1998.71062239.x. PMID 9832121. 
• Iismaa TP, Fathi Z, Hort YJ, et al. (1999). "Structural organization and chromosomal localization of three human galanin receptor genes". Ann. N. Y. Acad. Sci. 863: 56–63. doi:10.1111/j.1749-6632.1998.tb10683.x. PMID 9928159. 
• Lapsys NM, Furler SM, Henderson NK, et al. (1999). "A polymorphism in the human GALR3 galanin receptor gene (GALNR3)". Mol. Cell. Probes 13 (4): 325–7. doi:10.1006/mcpr.1999.0254. PMID 10441207. 
• Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208. 
• Berger A, Tuechler C, Almer D, et al. (2002). "Elevated expression of galanin receptors in childhood neuroblastic tumors". Neuroendocrinology 75 (2): 130–8. doi:10.1159/000048229. PMID 11867941. 
• Belfer I, Hipp H, Bollettino A, et al. (2007). "Alcoholism is associated with GALR3 but not two other galanin receptor genes". Genes, Brain and Behavior 6 (5): 473–81. doi:10.1111/j.1601-183X.2006.00275.x. PMID 17083333. 
• Runesson J, Sollenberg UE, Jurkowski W, et al. (2010). "Determining receptor–ligand interaction of human galanin receptor type 3". Neurochem. Int. 57 (7): 804–811. doi:10.1016/j.neuint.2010.08.018. PMID 20817064. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.