5-APDI
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| Systematic (IUPAC) name | |
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(±)-1-(2,3-dihydro-1H-inden-5-yl)propan-2-amine
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Oral |
| Identifiers | |
| CAS Number | 13396-94-6  |
| ATC code | None |
| PubChem | CID: 192600 |
| ChemSpider | 167142  |
| ChEMBL | CHEMBL6842 |
| Synonyms | 1-(5-indanyl)-2-aminopropane |
| Chemical data | |
| Formula | C12H17N |
| Molecular mass | 175.27 g/mol |
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5-(2-Aminopropyl)-2,3-dihydro-1H-indene (5-APDI), also known as indanylaminopropane (IAP), IAP (psychedelic), 2-API(2-aminopropylindane), indanametamine, and, incorrectly, as indanylamphetamine,[1] is an entactogen and psychedelic drug of the amphetamine family.[2][3] It has been sold by online vendors through the Internet and has been encountered as a designer drug since 2003,[1] but its popularity and availability has diminished in recent years.
5-APDI acts as a potent and weakly selective serotonin releasing agent (SSRA) with IC50 values of 82 nM, 1,848 nM, and 849 nM for inhibiting the reuptake of serotonin, dopamine, and norepinephrine, respectively.[2][3] It fully substitutes for MBDB but not amphetamine in trained animals, though it does produce disruption for the latter at high doses.[2]
5-ADPI has been classified as a class B drug under the Misuse of Drugs Act 1971 since 10 June 2014.
See also[edit]
- 5-MAPDI
- 3,4-Dimethylmethcathinone
- 5-APDB
- 6-APB
- 6-APDB
- 5-(2-Aminopropyl)indole
- DFMDA
- Ethylenedioxymethamphetamine
- Naphthylaminopropane
- Tetralinylaminopropane
References[edit]
- ^ a b Casale JF, McKibben TD, Bozenko JS, Hays PA (2005). "Characterization of the "Indanylamphetamines"". Microgram Journal 3 (1–2): 3–10.
- ^ a b c Monte AP, Marona-Lewicka D, Cozzi NV, Nichols DE (November 1993). "Synthesis and pharmacological examination of benzofuran, indan, and tetralin analogues of 3,4-(methylenedioxy)amphetamine". Journal of Medicinal Chemistry 36 (23): 3700–6. doi:10.1021/jm00075a027. PMID 8246240.
- ^ a b Parker MA, Marona-Lewicka D, Kurrasch D, Shulgin AT, Nichols DE (March 1998). "Synthesis and pharmacological evaluation of ring-methylated derivatives of 3,4-(methylenedioxy)amphetamine (MDA)". Journal of Medicinal Chemistry 41 (6): 1001–5. doi:10.1021/jm9705925. PMID 9526575.
External links[edit]
- The Vaults of Erowid - Indanylaminopropane
- Erowid Experience Vaults - Indanylaminopropane
- Bluelight Forums - The Big and Dandy Indanylaminopropane (IAP) Thread
- MadMax - Illustrated Synthesis of Indanylaminopropane
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