Cetamolol

Cetamolol
Names
	IUPAC name 2-[2-[3-(tert-Butylamino)-2-hydroxypropoxy]phenoxy]-N-methylacetamide
Identifiers
CAS Number	77590-95-5 (hydrochloride)
ChEMBL	ChEMBL2105989
ChemSpider	48483
Jmol interactive 3D	Image
PubChem	53698
	InChI InChI=1S/C16H26N2O4/c1-16(2,3)18-9-12(19)10-21-13-7-5-6-8-14(13)22-11-15(20)17-4/h5-8,12,18-19H,9-11H2,1-4H3,(H,17,20) Key: UWCBNAVPISMFJZ-UHFFFAOYSA-N ;
	SMILES CC(C)(C)NCC(COC1=CC=CC=C1OCC(=O)NC)O ;
Properties
Chemical formula	C16H26N2O4
Molar mass	310.39 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
	Infobox references

Cetamolol is a beta adrenergic antagonist.^[1]

Synthesis[edit]

Cardioselective b1-adrenergic blocker.

Cetamolol synthesis:^[2]^[3]

^ Klausner, MA; Irwin, C; Mullane, JF; Shand, DG; Leese, PT; Arnold, JD; Wollberg, W; Wagner, NB; Wagner, GS (1988). "Effect of cetamolol on epinephrine-induced hypokalemia". Journal of clinical pharmacology 28 (8): 751–6. doi:10.1002/j.1552-4604.1988.tb03210.x. PMID 2905711.
^ HL Tucker, DE 2453324 (1975) via Chem. Abstr., 83:96,993p
^ BE 767781 ; D. J. Lecount, C. J. Squire, U.S. Patent 4,059,622 (1971, 1977 both to ICI).

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Names

IUPAC name 2-[2-[3-(tert-Butylamino)-2-hydroxypropoxy]phenoxy]-N-methylacetamide
Identifiers
CAS Number	77590-95-5 (hydrochloride)
ChEMBL	ChEMBL2105989
ChemSpider	48483
Jmol interactive 3D	Image
PubChem	53698
InChI InChI=1S/C16H26N2O4/c1-16(2,3)18-9-12(19)10-21-13-7-5-6-8-14(13)22-11-15(20)17-4/h5-8,12,18-19H,9-11H2,1-4H3,(H,17,20) Key: UWCBNAVPISMFJZ-UHFFFAOYSA-N
SMILES CC(C)(C)NCC(COC1=CC=CC=C1OCC(=O)NC)O
Properties
Chemical formula	C₁₆H₂₆N₂O₄
Molar mass	310.39 g·mol⁻¹
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references