Laudexium metilsulfate
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| Systematic (IUPAC) name | |
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1-[(3,4-Dimethoxyphenyl)methyl]-2-[10-[1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]decyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-2-ium methyl sulfate
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| Clinical data | |
| Routes of administration |
IV |
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| Pharmacokinetic data | |
| Bioavailability | 100% (IV) |
| Identifiers | |
| CAS Number | 3253-60-9  |
| PubChem | CID 18618 |
| ChemSpider | 17584  |
| UNII | D067KDG4NU |
| Synonyms | Laudolissin |
| Chemical data | |
| Formula | C54H80N2O16S2 |
| Molar mass | 1077.35 g/mol |
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Laudexium metilsulfate is a neuromuscular blocking drug or skeletal muscle relaxant in the category of non-depolarizing neuromuscular-blocking drugs, used adjunctively in surgical anesthesia to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation.
Laudexium[1] is no longer used in clinical practice, though it was introduced clinically in the early 1950s.[citation needed] It has about half the potency, a slower onset of action and a duration of action much longer than that of d-tubocurarine.[2] As with all clinically established (as well as experimental agents) with a non-depolarizing mechanism of action, its pharmacological action can be antagonized by anticholinesterases.
The displacement of laudexium from clinical use was assured owing to recurrent reports of significant post-operative re-curarization.[3]
References[edit]
- ^ Taylor EP (1952). "Synthetic neuromuscular blocking agents. Part II. Bis(quaternary ammonium salts) derived from laudanosine". J Chem Soc: 142–145. doi:10.1039/JR9520000142.
- ^ Hunter AR (1955). "The action of laudexium in man and experimental animals". Br J Anaesth 27 (2): 73–79. doi:10.1093/bja/27.2.73. PMID 13230365.
- ^ Collier HO, Macauley B (1952). "The pharmacological properties of "laudolissin" a long-acting curarizing agent". Br J Pharmacol Chemother 7 (3): 398–408. doi:10.1111/j.1476-5381.1952.tb00707.x. PMC 1509112. PMID 12978243.
External links[edit]
- Neuromuscular blocking agents at the US National Library of Medicine Medical Subject Headings (MeSH)
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