Flestolol
From Wikipedia, the free encyclopedia
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| Names | |
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| IUPAC name
3-{[1-(Carbamoylamino)-2-methyl-2-propanyl]amino}-2-hydroxypropyl 2-fluorobenzoate
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| Identifiers | |
| 87721-62-8 | |
| ChemSpider | 50465 |
| Jmol interactive 3D | Image |
| PubChem | 55885 |
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| Properties | |
| C15H22FN3O4 | |
| Molar mass | 327.36 g·mol−1 |
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Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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| Infobox references | |
Flestolol is a short-acting beta adrenergic receptor antagonist.[1]
Synthesis[edit]
Flestolol synthesis:[2]
Acylation of glycidol (2) with the acid chloride 1 produces the ester 3. Reaction of that intermediate with amine 4, obtained by reaction of 1,1-dimethylethylenediamine with urea, gives flestolol (5).
References[edit]
- ^ Quon, CY; Stampfli, HF (1993). "Biochemical characterization of flestolol esterase". Research communications in chemical pathology and pharmacology 81 (3): 309–22. PMID 8235065.
- ^ Kam, Sheung Tsam; Matier, William L.; Mai, Khuong X.; Barcelon-Yang, Cynthia; Borgman, Robert J.; O'Donnell, John P.; Stampfli, Herman F.; Sum, Check Y.; Anderson, William G. (1984). "[(Arylcarbonyl)oxy]propanolamines. 1. Novel .beta.-blockers with ultrashort duration of action". Journal of Medicinal Chemistry 27 (8): 1007. doi:10.1021/jm00374a013. PMID 6146718.
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