5F-AB-PINACA
From Wikipedia, the free encyclopedia
Not to be confused with 5F-APINACA.
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| Systematic (IUPAC) name | |
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N-[(2S)-1-amino-3-methyl-1-oxobutan-2-yl]-1-(4-fluorobutyl)indazole-3-carboxamide
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| Clinical data | |
| Legal status |
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| Identifiers | |
| CAS Number | 1800101-60-3 |
| PubChem | CID 71301473 |
| UNII | 3L83B2298V |
| Chemical data | |
| Formula | C17H23FN4O2 |
| Molar mass | 334.40 g·mol−1 |
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5F-AB-PINACA is an indazole-based synthetic cannabinoid that is derived from a series of compounds originally developed by Pfizer in 2009 as an analgesic medication, and has been sold online as a designer drug.[1][2]
5F-AB-PINACA has been reported to be a potent agonist of the CB1 receptor and CB2 receptor with EC50 values of 0.48 nM and 2.6 nM respectively.[3] Its metabolism has been described in literature.[4][5]
Legality[edit]
China[edit]
As of October 2015 5F-AB-PINACA is a controlled substance in China.[6]
Germany[edit]
5F-AB-PINACA is an Anlage II controlled substance in Germany as of May 2015.[7]
Singapore[edit]
It is also controlled under the Fifth Schedule of the Misuse of Drugs Act (MDA) in Singapore as of May 2015.[8]
See also[edit]
References[edit]
- ^ "Patent WO/2009/106980 - Indazole derivatives".
- ^ "5F-AB-PINACA". Cayman Chemical. Retrieved 5 July 2015.
- ^ Samuel D Banister, Michael Moir, Jordyn Stuart, Richard C Kevin, Katie E Wood, Mitchell Longworth, Shane M Wilkinson, Corinne Beinat, Alxendra S Buchanan, Michelle Glass, Mark Connor, Iain S McGregor, Michael Kassiou (July 2015). "The pharmacology of indole and indazole synthetic cannabinoid designer drugs AB-FUBINACA, ADB-FUBINACA, AB-PINACA, ADB-PINACA, 5F-AB-PINACA, 5F-ADB-PINACA, ADBICA and 5F-ADBICA". ACS Chemical Neuroscience 6: 1546–59. doi:10.1021/acschemneuro.5b00112. PMID 26134475.
- ^ Ariane Wohlfarth, Marisol S. Castaneto, Mingshe Zhu, Shaokun Pang, Karl B. Scheidweiler, Robert Kronstrand, Marilyn A. Huestis (May 2015). "Pentylindole/Pentylindazole Synthetic Cannabinoids and Their 5-Fluoro Analogs Produce Different Primary Metabolites: Metabolite Profiling for AB-PINACA and 5F-AB-PINACA". The AAPS Journal 17 (3): 660–677. doi:10.1208/s12248-015-9721-0. PMID 25721194.
- ^ Moonhee Jang, Ilchung Shin, Jihyun Kim, Wonkyung Yang (February 2015). "Simultaneous quantification of 37 synthetic cannabinoid metabolites in human urine by liquid chromatography-tandem mass spectrometry". Forensic Toxicology 33: 221–234. doi:10.1007/s11419-015-0265-x.
- ^ "关于印发《非药用类麻醉药品和精神药品列管办法》的通知" (in Chinese). China Food and Drug Administration. 27 September 2015. Retrieved 1 October 2015.
- ^ "Gesetz über den Verkehr mit Betäubungsmitteln (Betäubungsmittelgesetz - BtMG) Anlage II (zu § 1 Abs. 1) (verkehrsfähige, aber nicht verschreibungsfähige Betäubungsmittel)" (in German). Retrieved 5 July 2015.
- ^ "CNB NEWS RELEASE". Central Narcotics Bureau (CNB). 30 April 2015. Retrieved 24 July 2015.
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