Daledalin
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| Systematic (IUPAC) name | |
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N-methyl-3-(3-methyl-1-phenyl-2,3-dihydro-1H-indol-3-yl)propan-1-amine
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| Identifiers | |
| CAS Number | 22136-27-2 23226-37-1 (tosylate) |
| ATC code | None |
| PubChem | CID: 31707 |
| ChemSpider | 29403 |
| UNII | IT56261A5A  |
| ChEMBL | CHEMBL2110924 |
| Chemical data | |
| Formula | C19H24N2 |
| Molecular mass | 280.409 g/mol |
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Daledalin (UK-3557-15) is an antidepressant which was synthesized and trialed for depression in the early 1970s, but was never marketed.[1][2][3] It is a selective norepinephrine reuptake inhibitor, with no significant effects on the reuptake of serotonin and dopamine, and no antihistamine or anticholinergic properties.[2] [4]
Synthesis[edit]
Daledalin synthesis:[5]
See also[edit]
References[edit]
- ^ David J. Triggle (1997). Dictionary of pharmacological agents. London: Chapman & Hall. ISBN 0-412-46630-9.
- ^ a b Canas-Rodriquez A, Leeming PR (1972). "N-Phenyl-2-indolinones and N-phenylindolines - New class of antidepressant agents". Journal of Medicinal Chemistry 15 (7): 762–770. doi:10.1021/jm00277a017.
- ^ Edwards JG, Ollerenshaw DP (1974). "Daledalin tosylate: a controlled trial in depressive illness". Current Medical Research and Opinion 2 (6): 305–12. doi:10.1185/03007997409114763. PMID 4614944.
- ^ Koe BK (December 1976). "Molecular geometry of inhibitors of the uptake of catecholamines and serotonin in synaptosomal preparations of rat brain". Journal of Pharmacology and Experimental Therapeutics 199 (3): 649–661.
- ^ Canas-Rodriguez, A. (1972). "N-Phenyl-2-indolinones and N-phenylindolines. New class of antidepressant agents". Journal of Medicinal Chemistry 15 (7): 762–770. doi:10.1021/jm00277a017.
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