Drd4 MGI Mouse Gene Detail - MGI:94926

Drd4
Gene Detail

Drd4
dopamine receptor D4
MGI:94926

D4R, Drd-4

protein coding gene

Chromosome 7
86.60 cM
Detailed Genetic Map ± 1 cM

Mapping data(6)

Chr7:141292006-141294999 bp, + strand
From Ensembl annotation of GRCm38

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

HomoloGene:20215 Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: DRD4
Protein SuperFamily: D2-like dopamine receptor
Gene Tree: Drd4

DRD4, dopamine receptor D4

Orthology source: HomoloGene

IDs:

HGNC:3025

NCBI Gene ID: 1815

neXtProt AC: NX_P21917

Human Synonyms: D4DR

Human Chr (Location): 11p15.5; chr11:637305-640706 (+) GRCh38.p2

Disease Associations: (1) Diseases Associated with Human DRD4

All mutations/alleles(8) : Gene trapped(1) Targeted(7)
Incidental mutations (data from APF , CvDC )

Homozygous mutants are less active in open field tests and have reduced responses to novelty, but they are locomotor supersensitivity to ethanol, cocaine, and methamphetamine.

Drd4 interacts with 13 markers (Mir130a, Mir140, Mir203, ...)

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All GO classifications: (68 annotations)

Process	activation of MAPK activity, adenylate cyclase-inhibiting dopamine receptor signaling pathway, ...
Component	axon, axon terminus, ...
Function	dopamine binding, dopamine neurotransmitter receptor activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Literature Summary: (6 records)

Data Summary: Results (247) Tissues (163) Images (17) Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	135
RT-PCR	112

cDNA source data(13)
Other mouse links: Allen Institute GENSAT GEO Expression Atlas
Other vertebrate links: Xenbase drd4 ; ZFIN drd4a, drd4b NEW

All nucleic(20) Genomic(3) cDNA(13) Primer pair(4)
Microarray probesets(4)

Ensembl Gene Model	ENSMUSG00000025496 (Evidence)
Entrez Gene	13491 (Evidence)
UniGene	41075
DFCI	TC1586290, TC1597652
DoTS	DT.60101540
NIA Mouse Gene Index	U008955
Consensus CDS Project	CCDS22007.1
International Mouse Phenotyping Consortium Status	Drd4

All sequences(19) RefSeq(4) UniProt(1)

All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(18 from dbSNP Build 137)

Resource	ID	Description
InterPro	IPR002185	Dopamine D4 receptor
InterPro	IPR000929	Dopamine receptor family
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
InterPro	IPR000276	G protein-coupled receptor, rhodopsin-like
Protein Ontology	PR:000001179	D(4) dopamine receptor

(Earliest) J:22009 Rao PA, et al., Allelic variation in the D4 dopamine receptor (DRD4) gene does not predict response to clozapine. Arch Gen Psychiatry. 1994 Nov;51(11):912-7
(Latest) J:202325 Hwang CK, et al., Circadian rhythm of contrast sensitivity is regulated by a dopamine-neuronal PAS-domain protein 2-adenylyl cyclase 1 signaling pathway in retinal ganglion cells. J Neurosci. 2013 Sep 18;33(38):14989-97
All references(81)

MGD-MRK-8894, MGD-MRK-8899, MGI:2142209

Sep	OCT	Nov
	18
2014	2015	2016

Representative Sequences	Length	Strain/Species	Flank
	genomic	ENSMUSG00000025496	Ensembl Gene Model \| MGI Sequence Detail	2994	C57BL/6J	± kb
	transcript	ENSMUST00000026569	Ensembl \| MGI Sequence Detail	1334	Not Applicable
	polypeptide	ENSMUSP00000026569	Ensembl \| MGI Sequence Detail	387	Not Applicable

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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