Pirenzepine
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| Systematic (IUPAC) name | |
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11-[(4-methylpiperazin-1-yl)acetyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one
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| Clinical data | |
| AHFS/Drugs.com | monograph |
| Identifiers | |
| CAS Number | 28797-61-7  |
| ATC code | A02BX03 |
| PubChem | CID: 4848 |
| IUPHAR/BPS | 328 |
| DrugBank | DB00670 |
| ChemSpider | 4682 |
| UNII | 3G0285N20N |
| KEGG | D08389 |
| ChEBI | CHEBI:8247 |
| ChEMBL | CHEMBL9967 |
| Chemical data | |
| Formula | C19H21N5O2 |
| Molecular mass | 351.403 g/mol |
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Pirenzepine (Gastrozepin), an M1 selective antagonist, is used in the treatment of peptic ulcers, as it reduces gastric acid secretion and reduces muscle spasm. It is in a class of drugs known as muscarinic receptor antagonists - acetylcholine being the neurotransmitter of the parasympathetic nervous system which initiates the rest-and-digest state (as opposed to fight-or-flight), the result being an increase in gastric motility and digestion.[1] It has no effects on the brain and spinal cord as it cannot diffuse through the blood–brain barrier.
Pirenzepine has been investigated for use in myopia control.[2][3]
See also[edit]
References[edit]
- ^ Stolerman, Ian P. (2 August 2010). Encyclopedia of Psychopharmacology. Springer. p. 811. ISBN 978-3-540-68698-9. Retrieved 26 June 2013.
- ^ Czepita D (2005). "Fundamentals of modern treatment of myopia". Ann Acad Med Stetin 51 (2): 5–9. PMID 16519089.
- ^ Walline JJ, Lindsley K, Vedula SS, Cotter SA, Mutti DO, Twelker JD (2011). "Interventions to slow progression of myopia in children". Cochrane Database Syst Rev (12): CD004916. doi:10.1002/14651858.CD004916.pub3. PMID 22161388.
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