Setiptiline

Setiptiline

Systematic (IUPAC) name
2-methyl-2,3,4,9-tetrahydro-1H-dibenzo[3,4:6,7]cyclohepta[1,2-c]pyridine
Clinical data
AHFS/Drugs.com	International Drug Names
Legal status	℞ (Prescription only)
Routes of administration	Oral
Identifiers
CAS Number	57262-94-9 N
ATC code	None
PubChem	CID: 5205
DrugBank	DB09304 Y
ChemSpider	5016 Y
UNII	7L38105Z6E Y
KEGG	D08511 Y
Chemical data
Formula	C19H19N
Molecular mass	261.36 g/mol
SMILES c42c(\C3=C(/c1ccccc1C2)CN(C)CC3)cccc4
InChI InChI=1S/C19H19N/c1-20-11-10-18-16-8-4-2-6-14(16)12-15-7-3-5-9-17(15)19(18)13-20/h2-9H,10-13H2,1H3 Y Key:GVPIXRLYKVFFMK-UHFFFAOYSA-N Y
NY (what is this?)  (verify)

Setiptiline (Tecipul), also known as teciptiline, is a tetracyclic antidepressant (TeCA) which acts as a noradrenergic and specific serotonergic antidepressant (NaSSA). It was launched in 1989 for the treatment of depression in Japan by Mochida.

Chemistry

Setiptiline has a tetracyclic structure and is a close analogue of mianserin and mirtazapine, with setiptiline being delta(13b,4a),4a-carba-mianserin, and mirtazapine being 6-aza-mianserin.

Pharmacology

Setiptiline acts as a norepinephrine reuptake inhibitor, α₂-adrenergic receptor antagonist, and serotonin receptor antagonist, likely at the 5-HT_2A, 5-HT_2C, and/or 5-HT₃ subtypes, as well as an H₁ receptor inverse agonist/antihistamine.

See also

• Aptazapine
• Mianserin
• Mirtazapine

References