Roxatidine acetate
From Wikipedia, the free encyclopedia
(Redirected from Roxatidine)
 |
|
| Systematic (IUPAC) name | |
|---|---|
|
2-oxo-2-(3-[3-(piperidin-1-ylmethyl)phenoxy]propylamino)ethyl acetate
|
|
| Clinical data | |
| Routes of administration |
Oral |
| Pharmacokinetic data | |
| Bioavailability | 80–90% |
| Protein binding | 5–7% |
| Metabolism | Hepatic deacetylation Minor involvement of CYP2D6 and CYP2A6 |
| Biological half-life | 5–7 hours |
| Excretion | Renal |
| Identifiers | |
| CAS Number | 78628-28-1  |
| ATC code | A02BA06 |
| PubChem | CID: 5105 |
| DrugBank | DB08806  |
| ChemSpider | 4926 |
| UNII | IV9VHT3YUM |
| KEGG | D08495 |
| ChEMBL | CHEMBL46102 |
| Chemical data | |
| Formula | C19H28N2O4 |
| Molecular mass | 348.437 g/mol |
|
|
|
|
| (what is this?) (verify) |
Roxatidine acetate is a specific and competitive histamine H2 receptor antagonist drug that is used to treat gastric ulcers, Zollinger–Ellison syndrome, erosive esophagitis, gastro-oesophageal reflux disease, and gastritis.[1][2]
Pharmacodynamic studies showed that 150 mg of roxatidine acetate were optimal in suppressing gastric acid secretion, and that a single bedtime dose of 150 mg was more effective than a dose of 75 mg twice daily in terms of inhibiting nocturnal acid secretion.[1]
It is available in countries including China, Japan, Korea, Germany, Italy, the Netherlands, Greece and South Africa.[2]
References[edit]
- ^ a b Murdoch D, McTavish D (1991). "Roxatidine acetate. A review of its pharmacodynamic and pharmacokinetic properties, and its therapeutic potential in peptic ulcer disease and related disorders". Drugs 42 (2): 240–260. doi:10.2165/00003495-199142020-00006. PMID 1717223.
- ^ a b BioSpectrum Bureau 1 November 2012 Sinhuan's generic heart drug gets production approval
|
 |
This drug article relating to the gastrointestinal system is a stub. You can help Wikipedia by expanding it. |
